Abel Ang, Albena Dinkova-Kostova, John Hayes and colleagues @dundee.ac.uk report that "The CNC-bZIP transcription factor #Nrf2 controls expression of matrix metalloproteases in murine #Macrophages"
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#Nrf2
Latest posts tagged with #Nrf2 on Bluesky
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Posts tagged #Nrf2
This review explores how #Nrf2 regulates #ferroptosis through iron metabolism and antioxidant defenses, connects key signaling pathways to #OrthopedicDiseases, and evaluates therapeutic potential and clinical gaps.
#OpenAccess: doi.org/10.1016/j.ge...
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🔥Hot Off the Press | #VitaminC Slows #OvarianAging
3-year monkey study: Oral vitamin C cuts oxidative stress, cell aging & follicle loss. Single-cell clocks show oocytes −1.35y, somatic cells −5.66y. Effects partly via #NRF2. Potential strategy against #ovarian #aging.
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A newly identified ferroptosis regulator controls lipid peroxidation through NRF2-dependent transcription, revealing a key vulnerability in cancer cell death pathways.
#Ferroptosis #NRF2 #LipidPeroxidation #RedoxBiology
www.nature.com/articles/s41...
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Exploring the Synergistic Effects of Flavonoids and Ascorbic Acid on Skin Protection #POLA #NRF2 #Flavonoids
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Review highlights the role of NRF2 signalling in chronic obstructive pulmonary disease: regulation of #ferroptosis and therapeutic implications 💊
#Immunology #redox #NRF2 #COPD
🔗 ino.to/P4uko9Z
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#Research
The role of Nrf2 in anoikis resistance and metastasis in anaplastic thyroid carcinoma doi.org/10.1186/s435...
#ATC #Nrf2 #AnoikisResistance #BCL #SLC7A11 #TherapeuticTarget
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📣 Join our webinar 🖥️ today to hear about biomarkers 🧬 of #NRF2 activation and their role in fighting chronic diseases 💊
@benbedphar.bsky.social
#BenBedPhar #COST #NRF2 #redox
🔗 www.antiox.it/webinars2025...
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📣 Newsletter alert: Check out the latest and sadly the last newsletter 🗞️ by @benbedphar.bsky.social COST Action CA20121 on recent cutting-edge #NRF2 research 🔬. Don't miss it 🎉
#BenBedPhar #EU #COSTaction #OxidativeStress
🔗 benbedphar.org/issue-13-oct...
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Great energy at the COST Action BenBedPhar meeting in Istanbul! Researchers from across Europe discussed the latest on NRF2 and its translational potential in chronic diseases. Collaboration, science & progress at their best! 💡
#BenBedPhar #NRF2 #Science
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📚 Our new review is out! @benbedphar.bsky.social WG3 dives deep into measuring #NRF2 activity across diseases and how to translate these biomarkers into clinical practice for better patient care.
Massive thanks to the fantastic team behind this work! 🙌
#NCD #COST #stress
🔗 doi.org/10.1016/j.re...
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This latest study shows that ROS accumulation reduces #OxidativeStress, #Nrf2, IL-6/IL-8, & activates Jak2/Stat3, leading to decreased #Inflammatory cell infiltration, opening new #therapeutic avenues for #ChronicHepatitis. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
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A fantastic finale at Kadir Has Istanbul for the #BenBedPhar MC&Scientific Meeting. Delivered WG3 report, presented our new research, and chaired #NRF2 scientific session. Grateful for an incredible 4 years with this brilliant #COST Action community—a truly unique journey 🎉
@benbedphar.bsky.social
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'Mechanistic Insights and Therapeutic Potential of Quercetin in Neuroprotection: A Comprehensive Review of Pathways and Clinical Perspectives' - a #BIOIntegration article on #ScienceOpen:
🖇️ #Quercetin #Neurodegeneration #Nrf2 #PrecisionMedicine
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Chinese researchers show how #NRF2 cell repair pathway is triggered by #oxidative #stress via the #DNA damage response pathway
www.science.org/doi/10.1126/...
I recommend imagining your DNA as a 6-foot long stress sensor in every cell in your body!
🧪 #health #science #aging #longevity #autophagy
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Study from Pusan National University Reveals Adverse Effects of Air Pollution on Lung Health and Immune Response #South_Korea #Pusan_National_University #Busan #Air_Pollution #NRF2
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Becoming mainstream ... get yours at asearedoxgold.com.
www.success.com/asea-cellula...
#nrf2activation
#Nrf2
#RedoxGold
#redoxsignaling
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A potential new immune checkpoint: The KEAP1-NRF2 pathway drives PTGIR expression, inducing CD8+ T cell exhaustion via metabolic changes. Blocking PTGIR enhances T cell function, pointing to alternative immunotherapy targets 💊.
#NRF2 #Immunology #ImmunoSky
🔗 rdcu.be/etTbI
🔗 rdcu.be/etTbb
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Most read on Osteosarcoma!
This review describes the multiple mechanisms of #Chemoradiotherapy resistance in #Osteosarcoma (OS) and the substantial role of #Nrf2 in the signaling regulatory network and discusses relevant therapeutic strategies. #medsky
#OpenAccess:
buff.ly/yauVF1T
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#BenBedPhar symposium took place in Galway @kasiawhysall.bsky.social where @mariaborjaa.bsky.social ECR REACT presented her work on #NRF2 and miRs in ageing!
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This integrated analysis of CodeBreaK 100 & 200 trials delves into biomarkers influencing sotorasib efficacy in KRAS G12C-mutated NSCLC.
#NatureMedicine
#Onco404 #Cancer #Kanser #LungCancer #Sotorasib #NSCLC #Biomarkers #PrecisionOncology #KRAS #TTF1 #KEAP1 #NRF2 #NFE2L2 #MedSky #OncSky
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Thrilled to share our latest publication in J. Med. Chem. a new regio- and stereoselective method to make nitro-fatty acids that strongly activate the NRF2 pathway, even in low oxygen
Proud to collaborate with Perecko & Vacek group.
#MedicinalChemistry #NRF2 #DrugDevelopment #Synthesis
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NRF2 in age-related musculoskeletal diseases: Role and treatment prospects
This review provides an overview of the relationship between #NRF2 and cellular processes such as oxidative stress, #apoptosis, inflammation, and autophagy, and explores the potential of targeted NRF2 regulation in the treatment of age-related #MusculoskeletalDiseases. #medsky
buff.ly/z0x0Wtm
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Particulate Matter (PM) 🏭 exposure disrupts immune balance ⚖️ and exacerbates conditions like #asthma by promoting TH2-driven inflammation 🔥 through #NRF2 pathway activation.
doi.org/10.1016/j.re...
#Immunology
#ImmunoSky
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Nrf2: A key regulator in chemoradiotherapy resistance of osteosarcoma
This review describes the multiple mechanisms of #Chemoradiotherapy resistance in #Osteosarcoma (OS) and the substantial role of #Nrf2 in the signaling regulatory network and discusses relevant therapeutic strategies. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
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New Blog Post: Oxidative Stress and the Role of Nrf2 in Your Health
#newblogpost #blogger #OxidativeStress #Nrf2
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NRF2 in age-related musculoskeletal diseases: Role and treatment prospects
This review provides an overview of the relationship between #NRF2 and cellular processes such as oxidative stress, #apoptosis, inflammation, and autophagy, and explores the potential of targeted NRF2 regulation in the treatment of age-related #MusculoskeletalDiseases. #medsky
buff.ly/ftLdjQt
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Be sure to also read about:
☘️ #Nrf2 activity regulation by #UbLigases (Albena Dinkova-Kostova et al)
☘️ roles of structured domains in #biomolecularcondensates (@jerelleaj.bsky.social et al)
☘️ PARPs and ADP-ribosylation-mediated #biomolecularcondensates (@leunglab.bsky.social et al)
...
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Just stumbled upon this interesting study on how #Nrf2 deletion amplifies air pollution-induced sinonasal #inflammation, highlighting the critical role of #antioxidant pathways in protecting against environmental exposures!
onlinelibrary.wiley.com/share/SYYKGM...
#immunology #upperairway 🧪
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This comprehensive review discusses the dualistic role of #NRF2 in disease pathophysiology, covering its protective and/or destructive roles in #autoimmune, respiratory, #cardiovascular, and metabolic diseases, as well as diseases of digestive system & #cancer.
www.sciencedirect.com/science/arti...
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