#Kras

@medchemexpress.bsky.social

3 days ago

🚀From Bench to Paper | Targeting #ATF4 in Elderly #KRAS #LungCancer
Age reshapes tumors: slows growth but boosts metastasis via integrated stress response. ATF4 drives plasticity; targeting ISR-ATF4 blocks spread&exposes glutamine vulnerability. High ATF4 links to poor survival—promising target.

0 1 0 0

Genes & Development

@genesdev.bsky.social

1 week ago

RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief
By Islam et al., and Luca Busino
➡️ https://genesdev.cshlp.org/content/40/5-6/308.abstract

Penn Medicine
#PROTAC #KRAS #cancer #cancertherapy

3 2 0 0

Erik Faber MD PhD

@fabermdphd.bsky.social

1 week ago

Emerging landscape of KRAS inhibitors in cancer treatment Alterations in KRAS, NRAS, and HRAS occur in roughly 20% of patients with cancer, making RAS one of the most intensively studied oncogenic targets. Th…

Nice review of #KRAS inhibitors: www.sciencedirect.com/science/arti...

Interesting that MRTX1133 development halted due to PK - with improved pre-clin testing, PK issues rarely lead to failure in trials

And KRAS amp seems to be major mech. of resistance - how can we exploit/prevent this?

0 0 0 0

@seldon-dengyue.bsky.social

1 week ago

5 innovadores medicamentos chinos, incluyendo inhibidores de:
🧬 KRAS G12C
🧬 EGFR de tercera generación
🧬 EGFR exon 20

#Fulzerasib #Sunvozertinib #Limertinib #Glecirasib #Garsorasib #Cáncer #Oncología #TerapiaDirigida #InnovaciónMédica #KRAS
#KRASG12C #EGFR #EGFRexon20 #DengYueMedicinasEnHongKong

0 0 0 0

@seldon-dengyue.bsky.social

1 week ago

🎯 4 dianas clave.
🧬 Tratamiento de precisión.
🌍 Impacto global.

📎 Más información: dengyuepharma.com
📧 info@dengyuemed.com
#CáncerDePulmón #CáncerDePulmónNoMicrocítico #NSCLC #Oncología #OncologíaClínica #SaludGlobal #EGFR #ALK #PD1 #PDL1 #KRAS #KRASG12C #DengYueMedicinasEnHongKong

0 0 0 0

@rcatanho.bsky.social

1 week ago

ASCO Publications

Mutaciones KRAS específicas de codón afectan las variables del adenocarcinoma ductal pancreático según la etapa de enfermedad al momento del diagnóstico #KRAS #PDAC ascopubs.org/doi/full/10....

0 0 0 0

ComplexPortal

@complexportal.bsky.social

2 weeks ago

🧬 Oncogenic KRAS mutations (pancreatic, colorectal, lung cancers) stabilize these complexes, sustaining growth signalling.

Explore RAS at the complex level → new therapeutic insights.

#RAS #KRAS #RASopathies #CancerBiology #ComplexPortal

2 1 0 0

cancergrace

@cancergrace.bsky.social

2 weeks ago

Support free patient education — donate today.

#LungCancer #KRAS #PatientAdvocacy

0 0 0 0

Genes & Development

@genesdev.bsky.social

3 weeks ago

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief
By Islam et al., and Luca Busino
➡️ genesdev.cshlp.org/content/early/2025/12/08...

#PROTAC #KRAS #cancer #cancertherapy

3 1 0 0

Pablo Álvarez Corredera

@cibered.com

1 month ago

#CancerCure #InnovationInMedicine #Biomedicine #FutureMedicine #HealthTech #LifeSavingResearch #CancerAwareness #KRAS #ExperimentalTherapy #DrugDiscovery #PreclinicalResearch #TranslationalMedicine #ScienceNews #GlobalHealth #FightCancer

0 0 0 0

The Oncology Network

@theoncologynetwork.bsky.social

1 month ago

Login / Sign Up – The Oncology Network Free access for registered Healthcare Professionals.

Intriguing new research: Triple-targeted therapy shows unprecedented efficacy in early pancreatic cancer models. Read here: t.ly/kTeMr #PDAC #KRAS #STAT3 #EGFR #OncologyNews #OncologyNetworkAustralia #Spain #CNIO #OncSky #MedSky #CanSky

1 0 0 0

MSK Library

@msklibrary.bsky.social

1 month ago

Synapse: Your Connection to our MSK Authors
Meet: Ethan Chi Ho Tse
Research Focus: Graduate Studies; NE WGS Student

Clinical and Molecular Characterization of KRAS-Mutated Renal Cell Carcinoma
synapse.mskcc.org/synapse/work...

#RenalCellCarcinoma #KRAS #CancerGenomics

0 0 0 0

Domandalo.com

@domandalo.bsky.social

1 month ago

Tumore al pancreas: la cura spagnola funziona davvero? Tripla terapia sperimentale regredisce il tumore al pancreas nei topi e frena le resistenze: che cosa cambia ora per i pazienti e la ricerca. Una combinazione farmacologica sperimentale ha eliminato t...

Tumore al pancreas: la cura spagnola funziona davvero? #TumorePancreas #Cancro #Oncologia #RicercaMedica #TriplaTerapia #KRAS #STAT3 #EGFR #Barbacid #PDAC #Salute #ClinicalTrials #Italia #Domandalo domandalo.com/spagna-cura-...

0 0 0 0

Don Porqué

@donporque.bsky.social

1 month ago

¿Cura del cáncer de páncreas? El CNIO borra tumores en ratón CNIO y Barbacid borran tumores de páncreas en ratones sin resistencias con triple terapia; claves, cifras en España y el salto a la clínica. El Centro Nacional de Investigaciones Oncológicas (CNIO) ha...

¿Cura del cáncer de páncreas? El CNIO borra tumores en ratón #CancerDePancreas #CNIO #MarianoBarbacid #Oncologia #Investigacion #Salud #Ciencia #TerapiasDirigidas #KRAS #Medicina #España #27deenero #felizmartes #PNAS #REDECAN donporque.com/cura-del-can...

0 0 0 0

Thiard News@F4F

@newsen.bsky.social

1 month ago

PAQ Therapeutics Secures $77 Million to Advance Cancer Treatment and Doses First Patient in Innovative Trial PAQ Therapeutics has announced a Series B extension funding totaling $77 million and has initiated patient dosing for its Phase 1 trial of PT0511, aimed at treating KRAS-driven cancers.

PAQ Therapeutics Secures $77 Million to Advance Cancer Treatment and Doses First Patient in Innovative Trial #USA #Burlington #PAQ_Therapeutics #KRAS #PT0511

0 0 0 0

deepseek

@deepseek.activitypub.awakari.com.ap.brid.gy

2 months ago

KRAS Inhibitors: Targeting the 'Undruggable' Mutation in 2025 and Beyond Your Science-based Guide to Wellness, Diet and Lifestyle Medicine

KRAS Inhibitors: Targeting the 'Undruggable' Mutation in 2026 and Beyond Once deemed "undruggable" due to its smooth surface and high affinity for GTP, the KRAS oncogene has become ...

#cancer #KRAS #inhibitors #pharma

Origin | Interest | Match

0 0 0 0

deepseek

@deepseek.activitypub.awakari.com.ap.brid.gy

2 months ago

KRAS Inhibitors: Targeting the 'Undruggable' Mutation in 2025 and Beyond Your Science-based Guide to Wellness, Diet and Lifestyle Medicine

KRAS Inhibitors: Targeting the 'Undruggable' Mutation in 2026 and Beyond Once deemed "undruggable" due to its smooth surface and high affinity for GTP, the KRAS oncogene has become ...

#cancer #KRAS #inhibitors #pharma

Origin | Interest | Match

0 0 0 0

Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

2 months ago

This review highlights #PDAC pathogenesis, focusing on KRAS–YAP–SFK signaling, the impact of #obesity via CREB/ATF1, and advances in therapies targeting #KRAS and YAP, while suggesting combinatorial prevention strategies. @uclacollege.bsky.social

#STTT: doi.org/10.1038/s413...

1 0 0 0

Therapeutic Advances in Medical Oncology

@tamedoncol.bsky.social

2 months ago

KRAS mutations matter! 🧬 In a cohort of 1667 advanced solid tumors, 28.1% had KRAS aberrations. G12D was most frequent (40.6%), and G12V/G13D linked to poor survival.
🔍 Learn more: buff.ly/Z7QSjPx
#Oncology #KRAS #CancerResearch

3 1 0 0

@arxivlens.bsky.social

2 months ago

Impact of KRAS codon-specific mutations on survival in metastatic CRC on trifluridine-tipiracil with/without bevacizumab.
Coker, Oluwadara et al.
Paper
Details
#KRAS #colorectalcancer #trifluridinetipiracil

0 0 0 0

Nature Cell Biology

@natcellbio.nature.com

2 months ago

RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer - Nature Cell Biology Treekitkarnmongkol, Katayama, Sankaran et al. identify RASH3D19 as a downstream target for KRAS signalling through miR-301a, which in turn leads to RAS activation and tumorigenesis. Targeting RASH3D19...

☕Treekitkarnmongkol, Katayama, Sankaran et al. identify RASH3D19 as a downstream target for #KRAS signaling through miR-301a, which leads to RAS activation & tumorigenesis. Targeting RASH3D19 inhibits growth of KRAS-mutant tumor cells in vivo. #PancreaticCancer
👉https://rdcu.be/eVPDm
bit.ly/4qlc7qU

4 1 1 0

Mark Fortner

@markfortner.bsky.social

2 months ago

A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer AbstractInhibitors of the oncogene KRAS hold promise for treating metastatic colorectal cancer (mCRC). In this study, we show that a selective, covalent small-molecule inhibitor of the active (ON) con...

An interesting article on overcoming resistance to KRASG12D inhibition in mCRC in a mouse model. | #cancer #CRC #KRAS

aacrjournals.org/cancerdiscov...

1 0 0 0

deepseek

@deepseek.activitypub.awakari.com.ap.brid.gy

2 months ago

KRAS Inhibitors: Targeting the 'Undruggable' Mutation in 2025 and Beyond Your Science-based Guide to Wellness, Diet and Lifestyle Medicine

KRAS Inhibitors: Targeting the 'Undruggable' Mutation in 2025 and Beyond Once deemed "undruggable" due to its smooth surface and high affinity for GTP, the KRAS oncogene has become ...

#cancer #KRAS #inhibitors #pharma

Origin | Interest | Match

0 0 0 0

Posts tagged #Kras