Latest posts tagged with #STAT3 on Bluesky
Integrated analysis of single-cell RNA-seq and ATAC-seq in lens epithelial cells: Unveiling the role of ATF6 as a key transcription factor
#SingleCellAnalysis reveals #ATF6 drives #EpithelialMesenchymalTransition in #LensEpithelialCells, promoting #fibrosis & #cataract progression; inhibiting ATF6 reduces #STAT3 activation, highlighting ATF6–TAK1 signaling as a therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
Intriguing new research: Triple-targeted therapy shows unprecedented efficacy in early pancreatic cancer models. Read here: t.ly/kTeMr #PDAC #KRAS #STAT3 #EGFR #OncologyNews #OncologyNetworkAustralia #Spain #CNIO #OncSky #MedSky #CanSky
Tumore al pancreas: la cura spagnola funziona davvero? #TumorePancreas #Cancro #Oncologia #RicercaMedica #TriplaTerapia #KRAS #STAT3 #EGFR #Barbacid #PDAC #Salute #ClinicalTrials #Italia #Domandalo domandalo.com/spagna-cura-...
#Article in #MedComm
Inhibition of FOS-Like Antigen 1 Reduces #Chemoresistance to #Temozolomide Through #Stemness Reprogramming via IL-6/STAT3Tyr705 #Pathway
doi.org/10.1002/mco2...
#FOSL1 #TMZ #Glioblastoma #IL_6 #STAT3
#Neutrophil-targeted #STAT3 inhibition reshapes #neutrophils into #antitumor effectors, suppresses tumor growth, and boosts cytotoxic CD8⁺ T-cell activity, highlighting STAT3 blockade as a promising #CancerImmunotherapy strategy. @unidue.bsky.social
#STTT: doi.org/10.1038/s413...
📢Join Our Upcoming Webinar | Advances in #Pancreatic #Cancer Therapy
🎙️Speaker: Mariano Barbacid, PhD, Group Leader, CNIO
🕒Nov 27, 2025 🔗https://ow.ly/5TLH50XnCWi
🌍Discuss how his team’s triple-target strategy (#KRAS, #EGFR, #STAT3) achieved complete and durable tumor regression in models of #PDAC.
#Research
STAT3 regulates NK and NKT cell differentiation through C-X3-C motif chemokine receptor 1 (CX3CR1) in hyper-IgE syndrome doi.org/10.1186/s435...
#STAT3 #mutation #Hyper_IgE #syndrome #NKcell #CX3CR1
#Research
Microwave dynamic therapy induces ferroptosis in colorectal cancer by targeting PTK2B to regulate STAT3-mediated GPX4 expression doi.org/10.1186/s435...
#ColorectalCancer #MWDT #Ferroptosis #PTK2B #GPX4 #STAT3
New research from D’Amico et al. shows that even when KRAS is removed from cancer cells, STAT3 continues to sustain tumorigenicity. This highlights STAT3 as a key vulnerability in KRAS-driven cancers
#KRAS #STAT3
www.embopress.org/doi/full/10....
🔥Interestingly, loss of myeloid STAT3 attenuated steatosis but aggravated inflammation and fibrosis
www.mdpi.com/2073-4409/14...
#Liver #STAT3 #Fibrosis
‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social
#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...
In #ESCC, aberrant #NotchSignaling promotes #TumorAngiogenesis through the NOTCH1–USP5–STAT3 axis, with #USP5 stabilizing #STAT3 to enhance pro-angiogenic factors, and targeting USP5 alongside #chemotherapy suppresses tumor growth.
#OpenAccess #STTT: doi.org/10.1038/s413...
Scientists from @unidue.bsky.social shows that targeting #STAT3 in #neutrophils reprograms them to an antitumor state, enhances cytotoxic CD8+ T cells, suppresses tumor growth, representing a promising #CancerImmunotherapy strategy. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
Figure 6. Schematic representation of proposed key molecular processes contributing to lesion development. This diagram illustrates the complex interplay between the complement system, coagulation cascade, extracellular matrix remodeling, and immune signaling pathways in the context of lesion formation. Coagulation factors cleave and activate complement components C3 and C5, initiating pro-inflammatory responses. Complement factor C3 also functions to stabilize clots by protecting them from fibrinolysis. The coagulation cascade is tightly regulated by members of the serpin superfamily, which modulate extracellular matrix remodeling through the induction of matrix metalloproteinase-9 (MMP-9) expression. Complement activation further engages the JAK/STAT signaling pathway, particularly STAT5, promoting mast cell activation. Activated mast cells, in turn, influence coagulation dynamics. Pharmacologic inhibition of the JAK/STAT pathway using JAK inhibitors can suppress STAT3 signaling and reduce mast cell degranulation, thereby modulating both inflammatory and thrombotic processes. These mechanisms highlight the therapeutic potential of JAK inhibitors in the context of endometriosis. Genes names in green signify differentially expressed genes, arrows show the directional change in gene expression in endometriosis lesions compared with control endometrium.
Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors—a network meta-analysis #STAT3 #MMP9 #C3 #MECFS #LongCovid
www.frontiersin.org/journals/imm...
NR2F1 binds directly with #STAT3 promoter and upregulates the expression of p-STAT3, to facilitate the #apoptosis and migration of lens epithelial cells via the JAK1/STAT3 pathway, resulting in epithelium fibrosis and #cataracts. #medsky
#OpenAccess:
Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity #STAT3 #Silibinin
bsky.app/profile/rene...
Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity #STAT3
www.nature.com/articles/s41...
Dr. Erica Schmitt is decoding inborn immune errors through a STAT3 gain-of-function lens. Her team’s mouse model mirrors human autoimmunity, showing B-cell subset accumulation and possible TFH cell contributions. #Immunogenetics #PedsResearch #STAT3 #Autoimmunity
pmc.ncbi.nlm.nih.gov/articles/PMC...
"IL-6 activates ERK/STAT3/Akt, and IL-22 activates ERK/STAT3/p38 MAPK." #IL6 #IL22 #STAT3
Preventive Effect of Vitamin C on Dextran Sulfate Sodium (DSS)-Induced Colitis via the Regulation of IL-22 and IL-6 Production in Gulo(−/−) Mice #IL22 #IL6 #STAT3
pmc.ncbi.nlm.nih.gov/articles/PMC...
Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjögren's syndrome #STAT3 #MECFS #LongCovid
ard.eular.org/article/S000...
3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing “glycolysis-lactate-STAT3″ and TIP60 signals-mediated Treg differentiation #DIM #AhR #STAT3 #MECFS #LongCovid
bsky.app/profile/rene...
3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing “glycolysis-lactate-STAT3″ and TIP60 signals-mediated Treg differentiation #DIM #AhR #STAT3 #MECFS #LongCovid
pubmed.ncbi.nlm.nih.gov/37793204/
🔬 Meet the Researchers Behind IMMERGE! 🔬
This week: Giulia Bressan & Dr. Bodo Grimbacher from @uni-freiburg.de!
Giulia will dive into STAT3 regulation & signaling to better understand immune function👩🔬🌟
Stay tuned for more IMMERGE scientists! 🚀
#IMMERGE #MSCA #IEI #Immunology #STAT3
#mTOR, #Stat3, and #Stathmin are known for their roles in cellular #growth and #cancer. Our work reveals their novel unpredicted functions in #cell_polarity during animal post-embryonic development.
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academic.oup.com/cei/article/...
“B cell dysregulation was evidenced by a loss of class-switched memory B cells and a significantly expanded CD19hiCD21lo B cell population, likely influenced by a skewed CXCR3+ TFH population. “
👉PB lymphocyte dysregulation identified in STAT3 GOF pt.
#STAT3 #GOF
Neuronal calcitonin gene-related peptide promotes prostate tumor growth in the bone microenvironment #CGRP #STAT3 #MECFS #LongCovid
bsky.app/profile/rene...
www.sciencedirect.com/science/arti...
"In addition, CGRP treatment activated extracellular signal-regulated kinases (ERKs)/ Signal transducer and activator of transcription 3 ( #STAT3) signaling in prostate cancer cells."
www.sciencedirect.com/science/arti...
"- CGRP treatment activates ERKs/ #STAT3 signaling in prostate cancer cells.
- CGRP may be a therapeutic target for advanced prostate cancer patients."
