Latest posts tagged with #LLPs on Bluesky
Congrats to the authors on a beautiful study! 🥳 Very elegant dissection of #LLPS by Rubisco inside the pyrenoid. Our Ape1’s linker is N-terminal, here it’s a separate protein—yet the physics feels strikingly similar. Cryo-ET of disordered networks is tough, but that’s why this work is so impressive.
Happy to share our deep characterization of #LLPS events modulating the DNA damage response (#DDR) through #53BP1 condensation promoted by #dincRNA
www.biorxiv.org/content/10.6...
You like #LLPS? #TeamTomo? #Rubisco? Check out our latest preprint!
What a great collaboration this has been!
Catching up after not being too active recently:
In one of our most #interdisciplinary #multimodal research articles published last year, we demonstrated that #LLPS #condensate dysregulation is very widespread in somatic #cancer. We also provided mechanistic explanations for #oncofusion #proteins.
Really valuable #preprint on biological #condensates, with some welcome terminological clarity:“Some papers equate condensates with #LLPS, but it is often neither clear whether the involved objects have liquid-like properties…nor whether they actually form by phase separation.”👏👇
Captured a very obvious phase separation and fusion process (nuclear localization of tobacco cells)
#LLPS #phaseseparation
Updated pre-print published on TDP-43 phase transition controlled by effective method, #LLPS, #LCD, #hnRNP
www.biorxiv.org/content/10.1...
Arthur Wong comments on s80 of Finance Act 2025, limited liability partnerships, in Finance Act edition of @thomsonreutersnews.bsky.social's British Tax Review, exploring the scope – and limitations – of this new legislation.
Read his article here: tinyurl.com/3w55r93n
#llps #s80FinanceAct2025
Don't forget to sign up for webinar on 27 Nov which Ten Old Square + @pumptax.bsky.social are giving on the major changes to the taxation of LLPs anticipated from Autumn Budget 2025.
Details here: tinyurl.com/3wxrrts7
#November2025budget #Autumn2025budget #LLPs
#Article in #MedComm
Targeting the Liquid–Liquid Separation Region of c-Maf for Treating Chromosomal Translocations in Multiple Myeloma doi.org/10.1002/mco2...
#BenzoylBenzoicAcid #cMaf #ChromosomalTranslocation #LLPS #MultipleMyeloma #IDRs #BBA
Many thanks #AntonioCostaFilho for the kind invitation to participate in the pre-meeting #SBBf course “Phase separation at membrane interphases: Biomolecular condensates in Actions”. Happy share session with #RumianaDimova #Condensates #LLPS #Bioimaging #Phasors #DANprobes
Lighting up this Diwali, just out @natcomms.nature.com non-equilibrium demixing & dissolution of chiral coacervates via intrinsic catalysis rdcu.be/eL8mo
#SystemsChemistry, #NonEquilibrium, #LifeLikeSystems, #LLPS
Grateful @IISERKolkata, @ANRF_India Swarnajayanti Award @DBTIndia
🖥️ New Publication Alert
Congratulations to Eric Schumbera, @dormannlab.bsky.social, @waltherlab.bsky.social & @miguelandrade66.bsky.social on their recent publication in BMC Genomics
#RGmotifs #IDRs #LLPS #HumanProteome #ComputationalMotifAnalysis
bmcgenomics.biomedcentral.com/articles/10....
🧬 📰 In a News & Views article published in @nataging.nature.com, Prof. Nektarios Tavernarakis discusses the discovery of specialized mRNA translation hubs that form by #LLPS on the surface of #mitochondria to supply key proteins on-site, thus, upholding mitochondrial integrity and function.
🚨Miao's and Weixiang's work on RNA transcription in DNA based condensates as nucleus mimics is now out in @natcomms.nature.com www.nature.com/articles/s41...
#syncell #DNA #condensate #LLPS.
Great work to understand transcription and LLPS in #crowded #viscoelastic environments @sfb1551.bsky.social
I am happy to share our new article on dynamic Eps15 and Dab2 networks in endocytosis studied by #NMR, and forming #LLPS. Research was done at @fmp-berlin.de and at the Institut de Biologie Structurale (IBS).
www.nature.com/articles/s41...
The Role of Protein Aggregation in Neural Cell Differentiation Revealed by ATRX Phase Separation #Japan #Tokyo #ATRX #neural_stem_cells #LLPS
💊 Small molecules that regulate phase separation may hold the key to treating cancer, neurodegeneration, and more. A recent review published in The FASEB Journal explores their mechanisms and drug discovery potential.
🔗 buff.ly/1hrR8Pv
#DrugDiscovery #LLPS #FASEBJournal
You may have noticed the C2A and C2A-B linker domains are not resolved in the average. The reason we found in the linker sequence. They are intrinsically disordered regions (IDRs): glycine-rich, polyampholytic and predicted to be highly prone to phase-separate.
🧵10/n #LLPS
Cells expressing Yap (stained green). Left side without condensate induction, right side two minutes after condensate induction, now filled with green dots.
Please share …. 🙏
📣 Very soon, we’ll have an open PhD position starting in fall 2025 — this time not on cilia, but on YAP & TAZ in podocytes and their regulation via LLPS. Interested candidates are welcome to contact us directly.
Supervision by Inês Cabrita […]
[Original post on social.cologne]
Our paper discovering novel roles for the retrovirus-like proteins RTL8 and PEG10 in shaping stress granule biology is now online on Science Advances! #llps #stressgranules
www.science.org/doi/full/10....
Our new preprint 🧬🔗 www.biorxiv.org/content/10.1...
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
Diagram of how intrinsically disordered proteins and phase-separated condensates coordinate presynaptic active zone structure and function. The presynaptic terminal organizes neurotransmission through dynamic and spatially structured protein assemblies. Synaptic vesicles (SVs) are distributed between a docked pool at the AZ and a reserve pool. Precise coupling between docked SVs and voltage-gated calcium channels enables rapid release, a process supported by an underlying AZ scaffold. Jin and colleagues propose that scaffold components, including Liprin-α and RIM, through their multifaceted intermolecular interaction, assemble into condensates via liquid-liquid phase separation (LLPS) that organize the molecular and functional architecture of the AZ. These dynamic assemblies help cluster SV release machinery while remaining responsive to synaptic activity. Thus, LLPS-driven Liprin-α/RIM condensates not only scaffold presynaptic architecture but also fine-tune vesicle priming and release dynamics. Created with BioRender.com.
Liprin-α & RIM form presynaptic liquid phase-separated condensates #LLPS. This Primer explores a @plosbiology.org study of how these assemblies shape #synaptic fidelity and what their disruption might mean in #neurodevelopmental disease 🧪 Paper: plos.io/3Tj5CX7 Primer: plos.io/3HTacJ9
Diagram of how intrinsically disordered proteins and phase-separated condensates coordinate presynaptic active zone structure and function. The presynaptic terminal organizes neurotransmission through dynamic and spatially structured protein assemblies. Synaptic vesicles (SVs) are distributed between a docked pool at the AZ and a reserve pool. Precise coupling between docked SVs and voltage-gated calcium channels enables rapid release, a process supported by an underlying AZ scaffold. Jin and colleagues propose that scaffold components, including Liprin-α and RIM, through their multifaceted intermolecular interaction, assemble into condensates via liquid-liquid phase separation (LLPS) that organize the molecular and functional architecture of the AZ. These dynamic assemblies help cluster SV release machinery while remaining responsive to synaptic activity. Thus, LLPS-driven Liprin-α/RIM condensates not only scaffold presynaptic architecture but also fine-tune vesicle priming and release dynamics. Created with BioRender.com.
Liprin-α & RIM form presynaptic liquid phase-separated condensates #LLPS. This Primer explores a @plosbiology.org study of how these assemblies shape #synaptic fidelity and what their disruption might mean in #neurodevelopmental disease 🧪 Paper: plos.io/3Tj5CX7 Primer: plos.io/3HTacJ9
Diagram of how intrinsically disordered proteins and phase-separated condensates coordinate presynaptic active zone structure and function. The presynaptic terminal organizes neurotransmission through dynamic and spatially structured protein assemblies. Synaptic vesicles (SVs) are distributed between a docked pool at the AZ and a reserve pool. Precise coupling between docked SVs and voltage-gated calcium channels enables rapid release, a process supported by an underlying AZ scaffold. Jin and colleagues propose that scaffold components, including Liprin-α and RIM, through their multifaceted intermolecular interaction, assemble into condensates via liquid-liquid phase separation (LLPS) that organize the molecular and functional architecture of the AZ. These dynamic assemblies help cluster SV release machinery while remaining responsive to synaptic activity. Thus, LLPS-driven Liprin-α/RIM condensates not only scaffold presynaptic architecture but also fine-tune vesicle priming and release dynamics. Created with BioRender.com.
Liprin-α & RIM form presynaptic liquid phase-separated condensates #LLPS. This Primer explores a @plosbiology.org study of how these assemblies shape #synaptic fidelity and what their disruption might mean in #neurodevelopmental disease 🧪 Paper: plos.io/3Tj5CX7 Primer: plos.io/3HTacJ9
#NatureReviews #DrugDiscovery #ProteinDisorder #ProteinEnsembles #TranscriptionFactors #BiomolecularCondensates #LLPS #imods #IDP #IDPs #HTS #HCS #Biophysics #StructuralBiology #Bioinformatics #ComputationalModeling #MolecularDynamics @viblifesciences.bsky.social @vubrussel.bsky.social
Development of #drugs that modulate #protein condensates is increasingly being seen as a route for #drugdevelopment.
Here, "protein condensate inhibitors" were developed to target cGAS benefitting from NanoTemper's Monolith X's in-solution binding affinity measurement to calculate their Kds
#llps
Hen and egg problem! If you look carefully into biological condensate literature you can find such sharp fronts, which went unnoticed - now we can explain this - and the importance can now be considered in biology.
#softmatter #biomolecularcondensates #DNAnanotech #LLPS #phaseseparation
