#Notch1

Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

2 weeks ago

YTHDF1 regulates chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer.
RNA regulation intersects with treatment resistance.
doi.org/10.1038/s413...
#ColorectalCancer #YTHDF1 #NOTCH1 #CancerStemness #ChemotherapyResponse #Epitranscriptomics

Life Science Alliance

@lsajournal.org

1 month ago

New Research article in LSA:
The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress
#Notch1 #CellBiology
@ctbatucsf.bsky.social
Take a look: 👇
www.life-science-alliance.org/content/9/4/...

Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

1 month ago

#YTHDF1 drives #ColorectalCancer stemness, #tumorigenesis, and #chemoresistance by enhancing m6A-dependent #NOTCH1 translation, while its inhibition suppresses #tumor growth and improves chemotherapy response.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Genes & Diseases Journal

@genesndiseases.bsky.social

1 month ago

Activated #Notch1 signaling drives #BMP2-induced endochondral #ossification in #MSCs by suppressing #Sox9-driven chondrogenesis and enhancing #VEGFA-mediated #angiogenesis, highlighting Notch1 as a target to improve #CartilageRegeneration.

#OpenAccess: doi.org/10.1016/j.ge...

Current Medical Science

@currentmedscience.bsky.social

2 months ago

Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1

This study demonstrates that #Prox1 suppresses #Retinoblastoma (RB) #CellProliferation and #DrugResistance through regulation of #Notch1, positioning Prox1 as a promising therapeutic target in RB and opening new avenues for #TranslationalOncology. #medsky

Read: link.springer.com/article/10.1...

Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

2 months ago

The m6A reader #YTHDF1 drives #ColorectalCancer stemness, #tumorigenesis, and #chemoresistance by binding #m6A‑modified #NOTCH1; targeting YTHDF1 improves #chemotherapy efficacy, offering a promising therapeutic strategy. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Rare Disease Advisor

@rarediseaseadvisor.bsky.social

5 months ago

BTK Inhibitors Overcome Poor Prognosis of CLL With NOTCH1 Mutations BTKis neutralized the adverse prognostic effect of NOTCH1 mutations in chronic lymphocytic leukemia (CLL), a study found.

Bruton tyrosine kinase inhibitors (#BTKis) appeared to offset the adverse prognostic impact of #NOTCH1 mutations in chronic lymphocytic leukemia (#CLL). Study in European Journal of Haematology.

Read more: https://bit.ly/4gTTqam

#RareDisease #Leukemia #Hematology #Oncology #OncSky #RareSky

Biomedical Center Munich / LMU Munich

@bmc-lmu.bsky.social

8 months ago

Published in @natcomms.nature.com :
💡Using #AI, Harald Steiner and his collaborator Dmitrij Frishman show how the enzyme γ-secretase, associated with #Alzheimer 's , chooses its target #proteins.

➡️ tinyurl.com/4v9dc5jt

Foto: Steiner Lab/BMC #amyloid #Notch1 #cell #carcinogenesis #XAI #neurobiology