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Our proposal for managing combination therapy while awaiting for susceptibility in Pseudomonas infections.

Find out more: journals.plos.org/plosone/arti... #AMSsky #IDsky #PsWatch

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Combined antipseudomonal therapy does not improve outcomes and may increase toxicity.
Its main role is ensuring appropriate empirical therapy in severe infections, with no proven benefit once susceptibility is known.

📖 A systematic review: www.tandfonline.com/doi/full/10.... #AMSsky #IDsky #PsWatch

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Epidemiology and Treatment of Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Infections

This is a classic review on Pseudomonas:
journals.asm.org/doi/epub/10....

And here you’ll find some more recent data on resistance against new betalactams:
www.sciencedirect.com/science/arti...

Hope you find it useful! #PsWatch #IDsky

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Can we use Ciprofloxacin for treating Levofloxacin-R Pseudomonas and viceversa? 🤔

#AMSsky #PsWatch 👇🏻👇🏻

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RNA-seq reproducibility of Pseudomonas aeruginosa in laboratory models of cystic fibrosis | Microbiology Spectrum RNA sequencing (RNA-seq) has revolutionized biology, but many steps in RNA-seq workflows can introduce variance, potentially compromising reproducibility. While reproducibility in RNA-seq has been tho...

Different approaches to preparing and sequencing bacterial RNA libraries capture comparable transcriptional profiles:
journals.asm.org/doi/10.1128/...

#microsky #PsWatch #bacteria

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The Pseudomonas Genome Database - Genome annotation and comparative genome analysis

The Pseudomonas Genome Database is now on Bluesky with the Pseudomonas.com web address! We encourage using the #pseudomonas hashtag to note interesting research #pseudomonas #bacteria #microsky #idsky #PsWatch

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Despite our growing antibiotic arsenal, non-fermenting GNB frequently keep leaving us without therapeutic options.

This article explores the present and the future of therapies against DTR NF-GNB: journals.lww.com/co-infectiou...

#PsWatch #AMSsky #IDsky

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Great initiative!
Would you please sign us up?

Also, we’ve created a dedicated feed on P. aeruginosa, in case you find it useful: bsky.app/profile/did:...

Tag your posts with #PsWatch to join the conversation!

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How long should we treat uncomplicated P. aeruginosa BSIs? Here’s a thread on the evidence we’ve got 👇🏻

#AMSsky #IDSky #PsWatch

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With our @shorten2trial.bsky.social RCT we will hopefully provide further specific data on P. aeruginosa BSIs, including those occurring in immunocompromised hosts 🤞🏻

#ShorterIsBetter #PsWatch #AMSsky #IDSky #IDOnc #TxID

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Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...

The recent BALANCE RCT (N=3600) proved 7-day course as the new standard for uncomplicated BSI!
www.nejm.org/doi/full/10....

However, <5% of BSIs were by P. aeruginosa (n=170), probably due to the exclusion of immunocompromised hosts, with no etiology-specific data provided.

#PsWatch #AMSsky #IDSky

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MDR-P. aeruginosa is usually underrepresented in studies on treatment duration, including the former meta-analysis.

In this later study on HAP/VAP by MDR-PsA, no improved outcomes were observed with treatments >8d either:
📚 bmcinfectdis.biomedcentral.com/articles/10....

#PsWatch #AMSsky #IDSky

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What's the best duration for treating uncomplicated P. aeruginosa-BSI?

This metaanalysis of observational studies (n=1746)
found no differences in recurrence+mortality for short (<10d) compared to prolonged treatments.

📖 www.journalofhospitalinfection.com/article/S019...

#PsWatch #AMSsky #IDsky

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Effectiveness of novel β-lactams for Pseudomonas aeruginosa infection: A systematic review and meta-analysis Novel β-lactams have in vitro activity against Pseudomonas aeruginosa (PA), but their clinical performances and the selection criteria for practical use are still not clear. We aimed to evaluate the e...

New β-lactams allow treating Pseudomonas that were untreatable, but… are they better than previous options?

This meta-analysis of RCTs shows they are not superior to prior alternatives when available: www.ajicjournal.org/article/S019...

👐🏻 Use them wisely, make them last
#PsWatch #AMSsky #IDsky

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Interested in learning about Pseudomonas aeruginosa?

We’ve created a dedicated feed where you will find from clinical trials to diagnostics or cutting-edge research: bsky.app/profile/did:...

Tag your posts with #PsWatch to join the conversation!

#IDSky #MicroSky #AMR #AMSsky #IDOnc #TxID

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