#WIS
#PlantandEnvironmentalScience
#RibonucleicAcid
#RNAStability
#TranslationEfficiency
#Pseudouridine
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#RNAstability
Latest posts tagged with #RNAstability on Bluesky
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Posts tagged #RNAstability
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Wonderful new paper by Khan et al.:
‘RNA modification: A contemporary review of pseudouridine (Ψ) and its role in functional plant biology’
tinyurl.com/3yvtywkc
#WIS
#PlantandEnvironmentalScience
#RibonucleicAcid
#RNAStability
#TranslationEfficiency
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RNA stability enhancers for durable base-modified mRNA therapeutics. #RNAstability #mRNAtherapeutics @natbiotech.nature.com
www.nature.com/articles/s41...
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This review explores both m⁶A-related and independent pathways through which #METTL16 regulates #RNAstability, emphasizes its critical role in #Cancer progression, and highlights METTL16 as a promising #therapeutic target in #Oncology. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
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🧬 Boosting mRNA stability through smart poly(A) tail design! New study explores chemical modifications that protect against degradation while preserving translation.
Read here: doi.org/10.1039/D5CB...
#RSCChemicalBiology #mRNA #RNAStability
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Genetic variants affecting RNA stability influence complex traits and disease risk. #RNAstability #DiseaseRisks #GeneticVariants #Genomics @natgenet.nature.com
www.nature.com/articles/s41...
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RNA methylation in retrotransposon control. #RNAmethylation #6mA #LTR #L1#ERV #RetrotransposonControl #RNAdecay #RNAstability #GenomeRegulation #CellularDifferentiation @cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...
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Left: Immunofluorescence for the indicated markers (BrdU, EdU, Ki67 and merge) in E12.5 cortical sections from control mice (top panel) and CNOT3 knockout mice (bottom panel). Right: Models for relationship between RNA turnover and gene expression, and the role of Cnot3 in cortical development. The schematic shows cortical development in WT (top panel) and Cnot3 cKO embryos (bottom panel). Loss of Cnot3 impacts development by p53-dependent and p53-independent mechanisms leading to apoptosis of progenitors and neurons, reduced neurogenic divisions, and longer cell cycle duration.
How does the regulation of RNA stability contribute to cortical development? This study profiles the #RNAstability landscape of the #cortex across development, revealing that the CCR4-NOT deadenylase complex is essential for corticogenesis in vivo 🧪 @plosbiology.org plos.io/3EtZjvN
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Left: Immunofluorescence for the indicated markers (BrdU, EdU, Ki67 and merge) in E12.5 cortical sections from control mice (top panel) and CNOT3 knockout mice (bottom panel). Right: Models for relationship between RNA turnover and gene expression, and the role of Cnot3 in cortical development. The schematic shows cortical development in WT (top panel) and Cnot3 cKO embryos (bottom panel). Loss of Cnot3 impacts development by p53-dependent and p53-independent mechanisms leading to apoptosis of progenitors and neurons, reduced neurogenic divisions, and longer cell cycle duration.
How does the regulation of RNA stability contribute to cortical development? This study profiles the #RNAstability landscape of the #cortex across development, revealing that the CCR4-NOT deadenylase complex is essential for corticogenesis in vivo 🧪 @plosbiology.org plos.io/3EtZjvN
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Left: Immunofluorescence for the indicated markers (BrdU, EdU, Ki67 and merge) in E12.5 cortical sections from control mice (top panel) and CNOT3 knockout mice (bottom panel). Right: Models for relationship between RNA turnover and gene expression, and the role of Cnot3 in cortical development. The schematic shows cortical development in WT (top panel) and Cnot3 cKO embryos (bottom panel). Loss of Cnot3 impacts development by p53-dependent and p53-independent mechanisms leading to apoptosis of progenitors and neurons, reduced neurogenic divisions, and longer cell cycle duration.
How does the regulation of RNA stability contribute to cortical development? This study profiles the #RNAstability landscape of the #cortex across development, revealing that the CCR4-NOT deadenylase complex is essential for corticogenesis in vivo 🧪 @plosbiology.org plos.io/3EtZjvN
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Any RNA biologists in the room? Does this makes sense? Is your favourite RBP in the list? #RNAbiology #RNAexport #RNAstability
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