Latest posts tagged with #WASF3 on Bluesky
Ever wonder why people with #ME/CFS or long #COVID feel exhausted for days after mild activity? This review discusses mitochondrial dysfunction as a potential shared mechanism and therapeutic target.
Abu Mohammad Syed, et al.
➡️ https://ow.ly/LO4p50Xe7f3
#mitochondria #ERstress #WASF3
directly with how mitochondria produce energy. In muscle samples from 14 patients compared with 10 healthy volunteers, most ME/CFS samples showed substantially higher WASF3 levels.
#ME/CFS #Mitochondria #WASF3 #AMD (Acquired Mitochondrial Disease) #SEID (Systemic Exertion Intolerance Disease)
So it probably identified a much larger group than ME/CFS.”
Nevertheless it would be great if the findings from the @decodemestudy.bsky.social found the same gene among the polygenic hits which can be involved in #ME/CFS. #WASF3
Our analysis identified eleven genes which may play important roles in certain aspects of #ME/CFS or related symptoms. In particular, the gene #WASF3 (aka WAVE3) possibly regulates brain cytokines involved in the mechanism of fatigue through the p38 MAPK regulatory pathway.
While we wait for the @decodemestudy.bsky.social #GWAS study results to be published 8/6/25 @ 7 pm GMT let us review these 2011 findings #ME/CFS #WASF3
Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data
WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome P. M. Heang et al. (2023) www.pnas.org/doi/10.1073/... #ME/CFS #WASF3 #Mitochondria
After extensive study, they noticed that Twinam’s body seemed to be producing more than the normal amount of a protein called WASF3. This protein, they discovered, was plugging up the process by which her body was trying to produce energy.
#WASF3 #ME/CFS
www.independent.co.uk/student/stud...
#WASF3 disrupts mitochondrial respiration and may be the factor mediating the core exertion intolerance & #PEM in patients affected by #ME/CFS medicalnewsbulletin.com/journal-club...
In 2023 a small group of NIH researchers, spearheaded by Dr P. Hwang made an important discovery that seems to explain one of the biological pieces in the disease we now call #ME/CFS. The paper was published in the prestigious PNAS medicalnewsbulletin.com/nih-scientis... #WASF3 #Mitochondria
Een EIWIT #WASF3 dat de energiecentra van cellen verstoort, kan een boosdoener zijn bij chronisch vermoeidheidssyndroom
Nieuw onderzoek biedt aanwijzingen over hoe uitputting kan ontstaan bij mensen met #MEcvs, en mogelijk gerelateerde aandoeningen zoals #LongCovid
www.science.org/content/arti...
identified eleven genes which may play important roles in certain aspects of #MECFS or related symptoms. In particular, the gene #WASF3 (aka WAVE3) possibly regulates brain cytokines involved in the mechanism of fatigue through the p38 MAPK regulatory pathway.
Meta analysis of ME/CFS through integration of clinical, gene expression, SNP and proteomic data
Vasyl Pihur1, Somnath Datta2, Susmita Datta2*
1The Johns Hopkins University, Published April 22, 2011 #WASF3
www.bioinformation.net/006/97320630...
