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Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases Genome-wide cfDNA fragmentomes are altered in liver disease and other morbidities and enable noninvasive detection of liver fibrosis and cirrhosis.

Epigenetics Update - Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases bit.ly/4aQzmEw

Jillian Phallen, Robert B. Scharpf, and Victor E. Velculescu (Johns Hopkins) reporting in Sci TM

#Epigenetics #cfDNA
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Discover the breakthrough at epigenometech.com

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Wisdom Bioscience establishes SAB with leading experts in #cfDNA, #oncology screening & #moleculardiagnostics: Drs Giulia Kennedy, Arnold Levine , John Sninsky, Martin Goldberg & Prof Tin Tin Su. #pressrelease🗞️https://wisdombioscience.com/ #oralcancer #dental #NGS #messengersinscience

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cfGWAS reveal genetic basis of cell-free DNA end motifs - Nature Communications Cell-free DNA is widely used in clinical testing, but its genetic basis remains unclear. Here, the authors perform cfGWAS in 28,016 pregnant women, identifying 15 loci linked to cfDNA end motifs and c...

Can we reuse NIPT cfDNA datasets to decode cfDNA biology? Nature Communications presents the first large-scale cfGWAS (28,016 pregnancies), revealing genetic regulators of cfDNA end motifs - promising for better liquid biopsy design. doi.org/10.1038/s414...

#cfDNA #cfGWAS #LiquidBiopsy #Genomics

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Epigenetics Update – A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection go.nature.com/4qGhUaj

#Epigenetics #cfDNA #Cancer #DNAm
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High-resolution insights without cell sorting; epigenometech.com

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Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection - Nature Reviews Cancer In this Review, Bruhm et al. provide a comprehensive overview of targeted and genome-wide cell-free DNA detection approaches, examining their potential to complement existing screening programmes or enhance early cancer detection for those cancers without effective screening methods.

🥳 Our 8th most downloaded #REVIEW in 2025:

Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection

#cfDNA #liquidbiopsy @NatResCancer
#NRCtop10of2025

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MobiCT: a UMI-based circulating tumor DNA analysis pipeline. #UMIs #cfDNA #Nextflow #Bioinformatics #Genomics #NARgenomicsAndBioinformatics 🧪🧬 🖥️
academic.oup.com/nargab/artic...

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New study: blood test using #cfDNA methylation detects multiorgan damage from immune checkpoint inhibitors — found in all patients with #irAE, sometimes weeks before symptoms. Suggests therapy causes systemic loss of immune tolerance. www.nejm.org/doi/full/10.... @funchainmd.bsky.social

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ISHLT Early Career-Led Literature Review in Pulmonology The December 2025 issue of ISHLT's Journal Watch explores topics in pulmonology, advanced lung failure, and transplant.

The December #ISHLTJournalWatch highlights pulmonology research, edited by @sirusjj.bsky.social.

Topics include gliptins and #CLAD, #cfDNA in #EVLP perfusate, lung allocation strategy, and #connectivetissue diseases in #lungtx.

#ISHLT #pulmsky #transplantsky

www.ishlt.org/about/news-d...

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Universal noninvasive prenatal diagnosis for monogenic disorders using cell-free plasma DNA. #cfDNA #MonogenicDisorders #PrenatalDiagnosis #GenomeMedicine
link.springer.com/article/10.1...

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The effects of bioinformatics preprocessing on cell-free DNA fragment analysis. #cfDNA #Bioinformatics #DataProcessing #FragmentAnalysis @gigascience.bsky.social 🧪🧬 🖥️
academic.oup.com/gigascience/...

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Heat, cold & time degrade liquid biopsy samples. The TAG FLEX-LB™ BCT stabilizes cfDNA, cfRNA, & total RNA for 7 days. One tube. Multiple biomarkers.
Protect Your Science. Perfect Your Signal. Meet us at #AMP2025 (Boston, Nov 11-15) to get your eval kit. #LiquidBiopsy #cfDNA

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We’re heading to Orlando for the International Society for Liquid Biopsy Annual Congress!
Booth #208 | 📅 Nov 1–3
Meet Giuseppe & Nuria to talk all things #LiquidBiopsy and #SamplePrep.
#cfDNA #cfRNA #Exosomes

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Proud to share a new study advancing non-invasive immune monitoring in cancer. Researchers found tumor-derived TCR clonotypes enriched in cfDNA and persisting >50 weeks in circulating T cells.

Proud that MiXCR powered large-scale TCR sequencing across tumor, blood, and cfDNA.

#cfDNA #TCRseq #TCR

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Home - ISLB 2025 Join us at ISLB 2025, the 7th Annual Congress of Liquid Biopsy, in Orlando, Florida, from November 1-3, 2025.

See you @ #ISLB2025 2025.islb.info TAG R&D Director Emily Medina, PhD presents a poster on Nov 1, 11:15am on TAG FLEX-LB performance results under real world thermal stress (37C/4C/ambient) and shares data on NGS apps, and stabilizing tricks for #cfRNA & #cfDNA. #LiquidBiopsy

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Pathology In Practice October 2025

New in Pathology in Practice: Dr Stephanie Anderson (Promega UK) explores donor-derived cfDNA as a non-invasive biomarker for kidney transplant monitoring, offering earlier insight into graft health

Read the full article in the October issue: https://tinyurl.com/PiPOct2025

#Transplantation #cfDNA

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Expanding the scope of non-invasive prenatal screening. #NIPS #cfDNA #cfRNA #Genetics @natgenet.nature.com
www.nature.com/articles/s41...

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Circulating Cell‐Free DNA of Bovine Leukemia Virus: A Promising Biomarker for Enzootic Bovine Leukosis Bovine leukemia virus (BLV) causes Enzootic bovine leukosis (EBL) in approximately 1%–5% of infected cattle after a long latent period. Few biomarkers effectively distinguish non-EBL from EBL cattle....

Quantitative analysis of BLV #cfDNA in cattle plasma achieves 100% sensitivity and specificity for diagnosing enzootic bovine leukosis - highlighting cfDNA as a highly effective #biomarker for veterinary #retrovirus #diagnostics🐄🧬🔍
📄 https://doi.org/10.1111/1348-0421.13231
👤 EVBC: Arif Ansori

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Cell-free DNA as a potential alternative to genomic DNA in genetic studies. #cfDNA #DNAseq #GeneticStudies #NARgenomicsAndBioinformatics
academic.oup.com/nargab/artic...

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The Role of cfDNA in Biliary Tract Cancer: Clinical and Prognostic Perspectives - OncoDaily Explores whether cfDNA is a game changer in BTC, highlighting its clinical value, high concordance with tissue testing, and prognostic insights.

The Role of cfDNA in Biliary Tract Cancer: Clinical and Prognostic Perspectives

oncodaily.com/oncolibrary/...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #cfDNA #BiliaryTractCancer #BTC

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Synapse: Your Connection to our MSK Authors
Meet: Jennifer Ann Kennedy
Research Focus: Medicine; Senior Genetic Counselor

Detection and characterization of RB1 mosaicism in patients with retinoblastoma receiving cfDNA test

synapse.mskcc.org/synapse/work...
#Retinoblastoma #RB1 #cfDNA

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FinaleToolkit: Accelerating Cell-Free DNA Fragmentation Analysis with a High-Speed Computational Toolkit. #cfDNA #FragmentationAnalysis #genomics #bioinformatics @biorxiv-bioinfo.bsky.social
www.biorxiv.org/content/10.1...

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Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid reflect medulloblastoma groups - npj Precision Oncology npj Precision Oncology - Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid reflect medulloblastoma groups

Excited to share our new paper: "Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid reflect medulloblastoma groups."

nature.com/articles/s41...

#Medulloblastoma #Fragmentomics #LiquidBiopsy #cfDNA #CerebrospinalFluid

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Non-Invasive Prenatal Testing (NIPT) Non-Invasive Prenatal Testing (NIPT)

NIPT is one of the fastest growing tools in modern prenatal care. But how does it work and why does it matter?

Our latest blog breaks it down in a clear, accessible way.

🔗 Read here: norgenbiotek.com/blog/non-inv...

#NIPT #Genomics #cfDNA #PrenatalScreening #Biotech #NorgenBiotek

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2025 Epigenetics Society International Conference | biomodal In the fast-evolving field of epigenetics, where researchers delve into the intricate mechanics of DNA, RNA, and chromatin to unravel the mysteries of disease

Exciting news! We’re thrilled to have @biomodalhq sponsoring and presenting at www.esconference25.com! Catch their session on how multiomic 6-base sequencing improves early colorectal cancer detection from cell-free DNA.

🔗 biomodal.com/events/2025-...

#epigenetics #cfDNA #colorectalcancer

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Die Canto Studie Die CANTO-Studie: Zellfreie DNA als Schlüssel zur Ursachenforschung beim ischämischen Schlaganfall

🧬 What causes a stroke when no cause is found?

The CANTO study explores cell-free DNA as a clue to cryptogenic strokes. Blood & clot analyses may reveal hidden mechanisms — a step toward better diagnosis, prevention & precision medicine.

#Stroke #cfDNA #ClinicalResearch

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We're actively developing a novel high-sensitive method for #cfDNA analysis and anticipate a preprint on that approach very soon. Exciting times ahead for #LiquidBiopsy in #GBM research! Kudo's to @tgenresearch.bsky.social for supporting this work and #PrecisionMedicine in general!

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Ultra-low-input cell-free DNA sequencing for tumor detection and characterization in a real-world pediatric brain tumor cohort - Acta Neuropathologica Communications Molecular profiling of pediatric central nervous system (CNS) tumors has important clinical utility for guiding diagnostic and therapeutic strategies. Cell-free DNA (cfDNA) from liquid biopsies has be...

We are excited to share our latest work highlighting the potential of liquid biopsies for pediatric CNS tumor patients - just published in Acta Neuropathologica Communications! Thank you to everyone who contributed to this study! doi.org/10.1186/s404... #LiquidBiopsy #cfDNA #PediatricNeuroOncology

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[NEW Blog] Looking for the best way to utilize #liquidbiopsy as a diagnostic tool? The new, minimally invasive PeCan-Seq deep sequencing method brings cost-effective analysis of #cfDNA to pediatric cancer. From @stjuderesearch.bsky.social

🎗️ bit.ly/44Ejt0J

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Research Technician (Genome Centre) - QMUL Jobs ID: 6545. Title: Research Technician (Genome Centre). Application Deadline:

Join our 🧬 #LiquidBiopsy team at Queen Mary University of London’s Blizard Institute Genome Centre as a 🔬 Research Technician. Develop cutting-edge pipelines to extract genetic and epigenetic information from #cfDNA and RNA.
🗓️ Deadline: 24th July 2025
✅ Apply: tinyurl.com/bdercjp4

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Synapse: Your Connection to our MSK Authors
Meet: Adam J Widman
Research Focus: Medicine; Assistant Attending

Error-corrected flow-based sequencing at
whole-genome scale and its application to
circulating cell-free DNA profiling
synapse.mskcc.org/synapse/work...
#ErrorCorrectedSequencing #cfDNA

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