#MEresearch

MEA Research Review: Post-Exertional Malaise (PEM) in ME/CFS and Long Covid - The ME Association This comprehensive research review outlines the key biological changes that […]

4 months ago

One of the free literature items available on our website is this review of research studies into PEM (Post-Exertional Malaise) in ME/CFS and Long Covid: https://meassociation.org.uk/3h01

#pwME #MECFS #LongCovid #PEM #MEResearch #LongCovidResearch

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Action for ME

@actionforme.bsky.social

5 months ago

A researcher wearing a mask, gloves, and a lab coat holds up a blood sample tube for examination. The image includes the Action for ME logo and a headline stating, “Researchers say they have developed the first accurate blood test to diagnose ME.

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🔬 Research news

Researchers at the University of East Anglia say they have developed the world's first blood test to diagnose ME

However, whilst acknowledging the research as an "interesting development", other researchers have offered cautionary responses to the results

#pwME #MEResearch

⬇️

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Tom Kindlon

@tomkindlon.bsky.social

5 months ago

5/
Oops, I forgot to say it was in the Spring 2024 edition www.meresearch.org.uk/wp-content/u...

#MEresearch #MECFSresearch

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youngEMERG

@youngemerg.bsky.social

6 months ago

🌟 Exciting News!
We’re thrilled to announce the upcoming YE International Workshop Series – Vienna 2025 🎉

📍 Vienna, Austria
📆 27–28 November 2025

Join us as we bring together early career researchers in #MECFS to connect, collaborate & spark new ideas! 🔬✨

#SaveTheDate #MECFS #MEresearch #ECR

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Haptoglobin phenotypes and structural variants associate with post-exertional malaise and cognitive dysfunction in myalgic encephalomyelitis - Journal of Translational Medicine Background Myalgic encephalomyelitis (ME) is a chronic, multisystem illness characterized by post-exertional malaise (PEM) and cognitive dysfunction, yet the molecular mechanisms driving these hallmark symptoms remain unclear. This study investigated haptoglobin (Hp) as a potential biomarker of PEM severity and cognitive impairment in ME, with a focus on Hp phenotypes and structural proteoforms. Methods A longitudinal case–control study was conducted in 140 ME patients and 44 matched sedentary healthy controls. In the discovery phase, global plasma proteomic profiling was performed in 61 ME patients and 20 controls before and after a standardized, non-invasive stress protocol in order to induce PEM. Associations between Hp levels, phenotype, and cognitive performance were assessed. In the validation phase, plasma Hp concentrations and proteoform composition were analyzed in an independent cohort of 89 ME patients and 24 controls using high-performance liquid chromatography (HPLC). Results ME patients demonstrated a significant reduction in Hp levels following post-exertional stress. Lower baseline Hp concentrations were associated with impaired cognitive performance. Hp phenotypes were differentially associated with symptom burden, with the Hp2-1 phenotype enriched in ME and linked to greater PEM severity and cognitive deficits compared to Hp1-1 and Hp2-2. HPLC analysis revealed altered Hp proteoform profiles in the Hp2-1 subgroup, including increased high-mass tetrameric and pentameric forms and shorter retention times indicative of structural changes. In contrast, the Hp1-1 phenotype was associated with milder symptoms and greater cognitive resilience. Conclusions These findings suggest that Hp phenotype and proteoform structure modulate the physiological response to post-exertion in ME, offering insight into the molecular basis of PEM and its clinical heterogeneity. Hp may serve as a translational biomarker for patient stratification and a potential therapeutic target to mitigate oxidative stress and cognitive dysfunction in ME.

6 months ago

New study finds that genetic differences in a blood protein may explain why people with ME experience severe crashes and brain fog after exertion.

https://tinyurl.com/467wec2a

#MECFS #MECFSResearch #MEResearch #PEM #MyalgicEncephalomyelitis

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Can science crack the mystery of ME? – podcast Madeleine Finlay speaks to science editor Ian Sample about a new study of how genes affect people’s chances of developing ME/CFS, and to Nicky Proctor who has ME and took part in the research. She als...

6 months ago

Can science crack the mystery of ME? – podcast | ME / Chronic fatigue syndrome | The Guardian #MEnotCFS #MEResearch #PwME #MyalgicE www.theguardian.com/science/audi...

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Kara Jane karajanesings.com Help Kara Jane Spencer raise money to support ME Association

7 months ago

Please Note: The original Just Giving page had a technical error - so the Spencer family have a new page should you wish to donate:

https://www.justgiving.com/page/kara-jane-sings-2

#InLimbo #KaraJane #MECFS #MyalgicEncephalomyelitis #SevereME #MEResearch #MEAssociation #RamsayResearchFund

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7 months ago

An interview with David Spencer, Kara Jane's dad, is expected to be broadcast this evening - on #SevereME Day, 8th August - on Channel 5 News in the UK. Sometime between 5pm and 5.45pm.
#InLimbo #karajane #MECFS #MyalgicEncephalomyelitis #MEResearch #MEAssociation

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Kara Jane's new album is out today - The ME Association ‘In Limbo' is the name of the new album released […]

7 months ago

The new album release for #SevereMEDay - 'In Limbo', by the late, great Kara Jane Spencer
meassociation.org.uk/2025/08/kara...
#InLimbo #karajane #MECFS #MyalgicEncephalomyelitis #SevereME #MEResearch #MEAssociation
#ramsayresearchfund #charityalbum

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7 months ago

MSN

People with ME have key genetic differences to other people, study finds

#SevereMEAwarenessWeek #SME2025
#PwME #MEnotCFS #MEresearch #MyalgicE

www.msn.com/en-gb/health...

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diamond

@diamondqc.bsky.social

7 months ago

interesting, ty for highlighting that 🙏
it's gonna take me a while to digest the entire study (as a layperson, but mostly bc #SevereME massively limits my cognitive capacity)
it's encouraging though to see the #DecodeME findings (deservedly so) getting more attention than #MEresearch typically does!

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diamond

@diamondqc.bsky.social

7 months ago

not previously utilised in #MEresearch found significant microglia activation bilaterally the insula, precuneus, parahippocampus, medial orbitofrontal cortex, temporal lobe; laterally the right amygdala, right rostral middle frontal gyrus, right posterior cingulate, left hippocampus & left thalamus!

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Key genetic differences found in people with chronic fatigue syndrome People with chronic fatigue syndrome, also known as myalgic encephalomyelitis, appear to have eight genetic signals that differ from those without the condition

7 months ago

Key genetic differences found in people with chronic fatigue syndrome | New Scientist

#PwME #MEnotCFS #MEresearch #MyalgicE

@decodemestudy.bsky.social

www.newscientist.com/article/2491...

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Scientists find link between genes and ME/chronic fatigue syndrome Large study suggests people’s genetics could ‘tip the balance’ on whether they would develop the illness

7 months ago

Scientists find link between genes and ME/chronic fatigue syndrome | ME / Chronic fatigue syndrome | The Guardian

#PwME #MEnotCFS #MEresearch #MyalgicE

@decodemestudy.bsky.social

www.theguardian.com/society/2025...

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The key genetic difference ME sufferers have from others – and what it means Scientists said the findings offer the first robust evidence that genes contribute to a person’s chance of developing the disease

7 months ago

The key genetic difference ME sufferers have from others – and what it means | The Independent

#PwME #MEnotCFS #MEresearch #MyalgicE

@decodemestudy.bsky.social

www.independent.co.uk/life-style/h...

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ME linked to your genetics – early study indicates Scientists said the findings offer the first robust evidence that genes contribute to a person’s chance of developing the disease.

7 months ago

ME linked to your genetics – early study indicates – Channel 4 News

#PwME #MEnotCFS #MEresearch #MyalgicE

@decodemestudy.bsky.social

www.channel4.com/news/me-link...

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People with ME have key genetic differences to other people, study finds The DecodeME study is described the largest of its kind in the world.

7 months ago

People with ME have key genetic differences to other people, study finds #PwME #MEnotCFS #MEresearch #MyalgicE
@decodemestudy.bsky.social

uk.news.yahoo.com/people-key-g...

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Initial DecodeME DNA Results - DecodeME 06 August 2025 The DecodeME team is delighted to announce that the initial analysis of 15,579 DNA samples is complete, and we have important news to share. Main findings from our analysis Your genes ...

7 months ago

Initial DecodeME DNA Results - DecodeME #PwME #MEresearch #MyalgicE #MEnotCFS
www.decodeme.org.uk/initial-dna-...

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7 months ago

If you're in the Bournemouth area, please consider sharing this with your friends/family to help promote the event!

#MEAssociation #MEResearch #MECFS #pwME #Fundraising #Odyssey

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