Latest posts tagged with #Microglial on Bluesky
LncRNA NPTN-IT1-201 Ameliorates Depressive-like Behavior by Targeting miR-142-5p and Regulating Inflammation and Apoptosis via BDNF
This study finds that #lncRNA NPTN IT1 201 sponges #miR 142 5p, upregulates BDNF, reduces #Inflammation, #Apoptosis, & #Microglial activation, helping to alleviate depressive-like behavior, promising a potential #therapeutic target for MDD. #medsky
To read: doi.org/10.1007/s115...
Verity F. T. Mitchener, Millie J. Thackray and I. Lorena Arancibia-Cárcamo from @crick.ac.uk discuss the glia-immune network, examining astrocytes and #oligodendrocytes as #microglial co-ordinators in health and disease 🔍️ 🔃
🔗 Read the #review here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
A cartoon showing a middle-aged mouse at an office desk, remembering (in a thought bubble) a childhood birthday, with his parent bringing him a cake with a single candle; cartoon glial cells are controlling a cable that links to his early memories. Infantile amnesia is the global loss of episodic and contextual memories formed in early life. Image credit: Birte Doludda
Infantile #amnesia limits our recall of early-life memories, but what is its cellular basis? @tjryan.bsky.social &co reveal that transient #microglial activity during postnatal development regulates infant #memory persistence & retrieval in mice @plosbiology.org 🧪 plos.io/4a0SoGH
A cartoon showing a middle-aged mouse at an office desk, remembering (in a thought bubble) a childhood birthday, with his parent bringing him a cake with a single candle; cartoon glial cells are controlling a cable that links to his early memories. Infantile amnesia is the global loss of episodic and contextual memories formed in early life. Image credit: Birte Doludda
Infantile #amnesia limits our recall of early-life memories, but what is its cellular basis? @tjryan.bsky.social &co reveal that transient #microglial activity during postnatal development regulates infant #memory persistence & retrieval in mice @plosbiology.org 🧪 plos.io/4a0SoGH
A cartoon showing a middle-aged mouse at an office desk, remembering (in a thought bubble) a childhood birthday, with his parent bringing him a cake with a single candle; cartoon glial cells are controlling a cable that links to his early memories. Infantile amnesia is the global loss of episodic and contextual memories formed in early life. Image credit: Birte Doludda
Infantile #amnesia limits our recall of early-life memories, but what is its cellular basis? @tjryan.bsky.social &co reveal that transient #microglial activity during postnatal development regulates infant #memory persistence & retrieval in mice @plosbiology.org 🧪 plos.io/4a0SoGH
www.sciencedirect.com/science/arti...
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC....
www.sciencedirect.com/ai?q=How+Non...
In ASD, #microglial activation & dysfunction have been consistently observed in both animal models and human studies
Product Citation 🦋
The FAM49B gene is downregulated in the normal aging process & in #PD pathology. StressMarq's #AlphaSynuclein PFFs helped to reveal that decreased FAM49B levels disrupt key #microglial functions.
Paper 🌼 https://go.nature.com/491OZIh
PFFs 🌺 https://bit.ly/2u9YHV2
#RepeatedMildClosedHeadInjury triggers sustained #neuroimmune and complement activation—marked by #microglial recruitment and #CognitiveImpairment—while post-injury #ComplementInhibition significantly mitigates these pathological changes.
#CoverPage in #STTT: doi.org/10.1038/s413...
Activation of the cGAS–STING pathway drives #RetinalInflammation in #endotoxin-induced #uveitis, while genetic deletion of #cGAS reduces #vitreous inflammation, vascular leakage, and #microglial activation. @fudan-university.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
#RepeatedMildClosedHeadInjury activates complement-driven neuroimmune responses, induces #microglial dysfunction and #neurodegenerative pathways, and post-injury #ComplementInhibition can reverse these effects,
#OpenAccess in #STTT: doi.org/10.1038/s413...
We were delighted to host Prof Delphine Boche ( #SouthamptonUni) for our #SHiMR_NTU Seminar! She shared insights into #neuroinflammation in #Alzheimer’s disease and innovative methods to study #microglial cells in the human brain. Thanks to Dr Shreyasi Chatterjee for hosting! @ntuneuro.bsky.social
🔍We mapped enzyme “
#Checkpoints” at single-cell resolution!
📌 #Microglial & #Endothelial hotspots=key regulators!
💡 Found #Sex-specific timing windows & microbial levers that can tilt #Kynurenine away from toxicity and toward protection.
@mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...
IT'S HERE ➡️ The first #MSNseminars of the new academic year! On Fri, Oct 17, 3pm, JOIN hosts @veronikakondev.bsky.social & Emily Birnbaum as @weillcornell.bsky.social's Sarah Naguib presents “Harnessing #Microglial #Resilience: genetic & therapeutic strategies across #Alzheimers, FTD & #Parkinsons".
- The chronic inflammation & elevated NETosis damage the endothelium, leading to a "leaky" BBB. Allows inflammatory factors & activated neutrophils to infiltrate CNS
- Neutrophils release NETs and other cytotoxic molecules directly within 🧠 , promoting neuroinflammation & #microglial activation.
Groundbreaking new paper on #Alzheimers disease: researchers found widespread "epigenome erosion" that is linked to cell-type-specific and region-specific changes that correspond with #microglial cell shifts, cognitive decline, and even cognitive resilience!
www.cell.com/cell/fulltex...
#STING limits #inflammation and damage to DNA. Deficiency→ increased neurological decline via blood-brain barrier breakdown. #Microglial STING signaling critical to prevent BBB breakdown and ensure neuromotor deficits in the aging brain. bit.ly/4p9lkDc bit.ly/462sobK [open access].
β-Amyloid induces #microglial expression of GPC4 and #APOE leading to increased neuronal tau pathology and toxicity
Brandon B. Holmes, Thaddeus K. Weigel, Jesseca M. Chung...James A. Wells #AlzheimersDisease #drosophila #amyloid #microglia @ucsanfrancisco.bsky.social
bit.ly/3HXP98J
'Early intervention anti-Aβ #immunotherapy attenuates #microglial activation without inducing exhaustion at residual plaques'
Lis de Weerd @lisdeweerd.bsky.social Selina Hummel, Stephan A. Müller...Christian Haass @haasslab.bsky.social #AlzheimersDisease #amyloid
bit.ly/3V8PDMa
Excited to be back at #AAIC2025! We already had a great start with an inspiring Imaging day yesterday. On Monday, I’ll present our work on how #microglial reactivity influences very early #amyloid accumulation on #PET. Come by poster 364 if you’d like to know more!
N6 #methyladenosine #RNA modification regulates #microglial #phagocytosis in the #APP/PS1 #mouse model of #Alzheimer #disease
#Genes & #Immunity @springernature.com
www.nature.com/articles/s41...
In vitro assay for #microglial #engulfment and #degradation of #synaptosomes in fixed and live samples, using #confocal imaging. Curious how it works? Check out our article (@ACCompagnion and @paolicellilab.bsky.social) in @cp-starprotocols.bsky.social.
star-protocols.cell.com/protocols/4321
The @sierralab.bsky.social lab is hiring!
Postdoctoral position in #microglial development (#IKUR)
www.achucarro.org/job/postdoct...
By #genetically removing STING in mice, researchers saw significant improvements such as better control of harmful #amyloid #plaques, healthier #microglial activity, and protection against #cognitive decline.
GENEWIZ is honored to be cited in this study, providing #RNAseq: hubs.ly/Q03sPs0B0
#CAR T cell therapy →white matter #microglial reactivity, chemokine expression → neurological #inflammation→ↆ #cognition in vivo. bit.ly/4kekKRI go.nature.com/3FpFp5Z
'Inhibition of soluble epoxide hydrolase confers #neuroprotection and restores #microglial homeostasis in a #tauopathy mouse model'
Shuo Wang, Chuangye Qi, Chetan Rajpurohit...Hui Zheng
@bcmhouston.bsky.social #AlzheimersDisease #microglia
bit.ly/42s0bdW
Our morning concluded with a few more trainee talks and another keynote speaker, Dr. Beth Stevens. #microglial #CNS #inflammation #aging
In this study, Lynn van Olst, Brooke Simonton, Alex Edwards, David Gate, et al. "uncover distinct #Microglial phenotypes in Aβ-immunized #AlzheimersDisease brains & reveal genes that control clearance of Aβ by microglia." Learn More @natmedicine.bsky.social www.nature.com/articles/s41...
Join us Wed. Feb 12th at 4pm CT for our Spring Seminar Series. Kimberley Bruce, PhD presents: "Targeting #Microglial #Metabolism in #Neurodegenerative Disease."
More info: bit.ly/4jjeaJw
#barshopseminarseries
'#APOE Christchurch enhances a disease-associated #microglial response to #plaque but suppresses response to tau pathology'
bit.ly/4h7SUoG
Research from Linh Le, Ania Majewska, et al. @urneuroscience.bsky.social @cvsuor.bsky.social demonstrates sex-dependent differences in the #Microglial response to CSF1R inhibitor, suggests sex-dependent differential survival mechanisms that warrant further investigation. www.cell.com/cell-reports...
