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Posts tagged #T2DM

Estimating prevalence and predictors of glucose-lowering overtreatment among older adults with type 2 diabetes in long-term care and community settings: a machine learning–based cohort study Objective To estimate the prevalence of potential overtreatment of type 2 diabetes mellitus (T2DM) among older adults and to develop and compare predictive models to identify patient and physician cha...

🆕 UBC TI publication:

Nearly 30% of older adults with type 2 #diabetes in BC may be over-treated, despite already having A1C ≤7% 😮 ⚠️
bmjopen.bmj.com/content/16/3...

#OverTreatment #T2DM #LTC #prescribing

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RCT data showing that canagliflozin reduces myocardial fibrosis in high-risk #T2DM, providing imaging evidence for its cardioprotection #DiabetesResearch #SGLT2i

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Canagliflozin attenuates CMR-quantified myocardial fibrosis in individuals with type 2 diabetes mellitus at high cardiovascular risk: a randomised open-label controlled trial - Diabetologia Aims/hypothesis We aimed to investigate canagliflozin’s effects on myocardial fibrosis, cardiac structure and function, and microcirculation in high-cardiovascular-risk type 2 diabetes mellitus throug...

Novel RCT: Canagliflozin reduces myocardial fibrosis (by CMR) in high-risk #T2DM, providing imaging evidence for its cardioprotection. A mechanism beyond glycaemic management. #SGLT2i #CardioDiabetes #HeartFailure #DiabetesResearch link.springer.com/article/10.1... 🔓

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Pharmacovigilance analysis of the association between SGLT-2 inhibitors and diabetic foot infections using the FAERS database: An observational study Sodium-glucose cotransporter-2 (SGLT-2) inhibitors are widely used for the management of type 2 diabetes mellitus (T2DM) and heart failure (HF). SGLT-…

#health #publichealth #agedcare #diabetes #NCDs #geriatrics #primaryhealthcare #healthliteracy #aging #T2D #T2DM #healthinformatics

Canagliflozin shows a
163-fold higher diabetic foot infection signal
in adverse events data
than other SGLT-2 inhibitors.
.
www.sciencedirect.com/science/arti...

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Biomarker Liver Fibrosis

Indian #T2DM + #MASLD cohort n=789

FIB-4 & NAFLD Fibrosis Score performed poorly (sensitivity ~22%) vs FibroScan/Vibration-controlled transient elastography for advanced fibrosis (LSM≥9.7 kPa)

#DiabetesMetabSyndr 2026
www.sciencedirect.com/science/arti...

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Orforglipron offers greater weight loss for people with diabetes than oral semaglutide Novel weight-loss pill orforglipron (Emgality; Eli Lilly) offers patients with type 2 diabetes mellitus (T2DM) better blood sugar control and more weight loss than semaglutide — the only other GLP-1…

Patients with #type2diabetes taking weight-loss pill #orforglipron achieved better blood sugar control and more weight loss than those on #semaglutide in pill form, research shows

#weightloss #Emgality #EliLilly #diabetesmellitus #T2DM

buff.ly/vRMS2ir

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Congrats to Yolanda, Ayush and Isha Jain’s lab. Really cool work that may revolutionize a variety of disease processes including #T2DM and possibly cancer.

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Co-existing T2DM and MASLD: A cardiovascular high-risk phenotype. | Predictive Health Intelligence In Practice with Dr Denver: Co-existing T2DM and MASLD: A cardiovascular high-risk phenotype. Public health systems are facing a tsunami of metabolic disease, and the downstream impact is stark. Car...

Co-existing #T2DM + #MASLD is a cardiovascular high-risk phenotype, and often missed until too late.

~2x higher #MACE risk vs T2DM alone, even beyond traditional risk factors.

Katie Denver breaks down why and what it means for earlier identification.

Read: www.linkedin.com/posts/predic...

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Working on my health. In 3 months my A1C went from 7.6 down to 6.5. Trying to be here for my grandsons graduation! Walking every day 😁
#a1c #diabetes #T2DM #T2D #walking

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3🧵Prof William S Yancy has spent years researching how elevated #carbohydrate intake drives #metabolic risk, setting the stage for #T2DM, #obesity, #reflux & #cardiovascular disease.

Risk accumulates across systems 🧨🔥not in isolation.

#ReclaimingHealth #NewZealand

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Environmental Endocrine‐Disrupting Chemicals, Pancreatic β‐Cells, and Type 2 Diabetes Mellitus Objective To clarify the link between environmental pollution and diabetes risk by focusing on pancreatic β-cells as key targets of environmental insults, with emphasis on the role of endocrine-disr...

#ecology #health #gerontology #SDGs #endocrinology #diabetes #nephrology #CKD #publichealth #histology #healthequity #NCDs #healthliteracy #T2D #T2DM #ecotoxicology #ESRD

Environmental pollutants
play a significant role in

β-cell dysfunction
and diabetes.
.
onlinelibrary.wiley.com/doi/full/10....

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Mitonuclear Discordance and Gout, Type 2 Diabetes and Chronic Kidney Disease in Aotearoa New Zealand Indigenous Māori and Pacific People Background Mitochondrial proteins are encoded by both mitochondrial- and nuclear-encoded genes. Because mitochondrial DNA (mtDNA) is maternally inherited, admixed individuals may have different ance...

An Early View: Mitonuclear discordance has been proposed to impair #mitochondrial function in admixed populations.

In 2,301 Māori and Pacific peoples in Aotearoa New Zealand, higher discordance was associated with lower risk of #gout and #T2DM, particularly in the prevalent B4a1a mtDNA haplogroup.

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GLP-1 Receptor Agonists and Risk of Optic Nerve or Vision-Threatening Events in Patients With Type 2 Diabetes or Cardiometabolic Diseases: A Meta-analysis of Randomized Controlled Trials BACKGROUND. Data concerning glucagon-like peptide 1 receptor agonists (GLP-1 RAs) on risk of ischemic optic neuropathy (ION) are conflicting.PURPOSE. We sy

In pts w #T2DM & cardiometabolic dz, GLP-1 RAs were not associated w increased risk of optic nerve/vision-threatening events #MedSky #GLP1 #OphthoSky
diabetesjournals.org/care/article-abstract/doi/10.2337/dc25-1929/164303/GLP-1-Receptor-Agonists-and-Risk-of-Optic-Nerve-or

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In silico computational screening and molecular dynamics analysis unveil Moringa oleifera phytochemicals as a promising PPAR-γ receptor agonist for targeted diabetes management strategies

In silico computational screening and molecular dynamics analysis unveil Moringa oleifera phytochemicals as a promising PPAR-γ receptor agonist for targeted diabetes management strategies

Screening 42 #Phytochemicals from #MoringaOleifera identified #Epicatechin and #Genistein as potent PPAR γ modulators with superior binding affinity to #Rosiglitazone, underscoring their promise as natural #Antidiabetic agents for #T2DM therapy.
Open Chemistry: doi.org/10.1515/chem...

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Protective effects of methanolic broccoli (Brassica oleracea var. italica) extract on metabolic dysfunction and hypothalamo-hypophyseal axis oxidative stress in a rat model of diet-induced type 2 diabetes mellitus

Protective effects of methanolic broccoli (Brassica oleracea var. italica) extract on metabolic dysfunction and hypothalamo-hypophyseal axis oxidative stress in a rat model of diet-induced type 2 diabetes mellitus

Scientists show #MethanolicExtract of #BrassicaOleracea florets protects #cafeteria diet induced #T2DM rats by normalizing #glycemia, restoring lipid profiles, reducing #OxidativeStress, and safeguarding hypothalamo hypophyseal tissues.

Open Chemistry: doi.org/10.1515/chem...

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Longitudinal associations of long-term exposure to ambient air pollution, residential greenness, and air temperature with type 2 diabetes subphenotypes: Results from the KORA cohort study To examine the association between environmental exposures and specific type 2 diabetes (T2D) subphenotypes.We categorized T2D participants from the K…

#endocrinology #diabetes #health #publichealth #T2D #T2DM #ecotoxicology #exposome #healthinformatics #environment

Association between
air pollution
and insulin resistance
.
www.sciencedirect.com/science/arti...

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#health #agedcare #menopause #ecology #SDGs #gerontology #exposome #healthinformatics #publichealth #primaryhealthcare #T2D #T2DM #Alzheimers #ecotoxicology #NCDs

Robust dose-dependent positive association between

blood levels of cadmium (Cd)

and diabetes.
.
www.besjournal.com/fileSWYXYHJK...

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What is the association between preoperative #GLP-1 receptor agonist use and periop #respiratory complications in #T2DM patients?

Read the full article here: www.bjanaesthesia.org.uk/article/S0007-0912(25)00...

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❓Is #Anxiety hiding early #Dementia cases?🤯Misdiagnosis delays help!⏳ #T2DM = longer diagnosis time! @mdpiopenaccess.bsky.social #MentalHealthMatters #NeuroScience #EarlyDiagnosis
🧪 Dive deeper 📚
www.mdpi.com/2227-9059/13...

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Born #OTD, Carl Cori was one of the first #LaskerAward winners. He was recognized for contributions to the knowledge of carbohydrate metabolism, which clarified the action of insulin in diabetes. #T2DM ow.ly/lMOa50CtPiw 🧪

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❓Ever wondered why young minds fade too soon? 😨 Symptoms before 65 get mislabeled 🧩 Key risks: #T2DM & #TBI 🚨 @mdpiopenaccess.bsky.social #DementiaAwareness #YoungOnsetDementia #BrainHealth
Read + share 👉
www.mdpi.com/2227-9059/13...

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TI Annual Course
ti.ubc.ca/annual-cours...

Speaking now: Dr. Guillaume Grenet

"Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors in type 2 diabetes"

👎 LOW evidence for primary CVD prevention

#DrugEvidence25 #CME #MedEd #T2DM #diabetes #GLP1

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TI Annual Course
ti.ubc.ca/annual-cours...

Speaking now: Dr. Guillaume Grenet

"Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors in type 2 diabetes"

👎 LOW evidence for primary CVD prevention

#DrugEvidence25 #CME #MedEd #T2DM #diabetes #GLP1

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TI Annual Course
ti.ubc.ca/annual-cours...

Speaking now: Dr. Guillaume Grenet

"Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors in type 2 diabetes"

#DrugEvidence25 #CME #MedEd #T2DM #diabetes #GLP1

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❓Are we treating symptoms, not causes? 🧠 Many labeled “ #Psychiatric” first 🏷️ #T2DM slows correct diagnosis!🔍 @mdpiopenaccess.bsky.social #BrainResearch #PrecisionMedicine #YOD
Spread awareness! 📢
www.mdpi.com/2227-9059/13...

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Alternative sweetener sorbitol linked to liver disease Sweeteners such as aspartame, found in Equal packets, sucralose (Splenda), or sugar alcohols are often seen as healthier alternatives to food with refined sugar (glucose). But that assumption is being...

#geriatrics #agedcare #nutrition #health #dietetics #diabetes #publichealth #healthliteracy #hepatology #aging #gerontology #T2D #T2DM #sugar #foodsystems

Alternative sweetener sorbitol
linked to liver disease
.
medicalxpress.com/news/2025-11...

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❓Is #Anxiety hiding early #Dementia cases?🤯Misdiagnosis delays help!⏳ #T2DM = longer diagnosis time! @mdpiopenaccess.bsky.social #MentalHealthMatters #NeuroScience #EarlyDiagnosis
🧪 Dive deeper 📚
www.mdpi.com/2227-9059/13...

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❓Ever wondered why young minds fade too soon? 😨 Symptoms before 65 get mislabeled 🧩 Key risks: #T2DM & #TBI 🚨 @mdpiopenaccess.bsky.social #DementiaAwareness #YoungOnsetDementia #BrainHealth
Read + share 👉
www.mdpi.com/2227-9059/13...

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Illustrative

Illustrative

A new systematic review and meta-analysis suggests that adults with type 2 diabetes mellitus, or at high risk of it, may lose on average 2.4kg more weight with orlistat at 12 months of follow up
➡️ doi.org/10.3399/BJGP...
#SystematicReview #T2DM

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🦃Our November Issue is now out 🥧

📗 Cover: Cabezudo et al. IF staining in HEK293T of WAC, a regulator of mTORC1 in response to glucose and glutamine availability

🔦 Explore the contents here

🔓https://buff.ly/BaMtm3s

#Biochemstry #T2DM #mTORC1 #scRNAseq #Tamoxifen #ProstateCancer

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