Latest posts tagged with #TumorMicroEnvironment on Bluesky
IL-7 agonist #EfineptakinAlfa (NT-I7) reshapes the #TumorMicroenvironment, expanding T, B, DC, and stem-like CD8 T cells while inducing TLS-like aggregates enriched in PD-L1, suggesting synergy with #PD1blockade.
#OpenAccess: doi.org/10.1016/j.ge...
Researchers @roswellpark.bsky.social show that the #Exocyst complex mediates fungal-induced IL-33 release from #Cancer cells, identifying a novel secretory mechanism that links fungal-induced immune signaling to #TumorMicroenvironment modulation.
#OpenAccess: doi.org/10.1038/s413...
This #STTT study introduces a bimetallic nanobomb that activates the STING pathway and boosts BiTEs-mediated #PhotothermalTherapy, effectively remodeling the #Immunosuppressive #TumorMicroenvironment in #ColorectalCancer.
#OpenAccess: doi.org/10.1038/s413...
🚨 Few spots left!
Join the 7th International Conference on #Cytokines in #Cancer
📅 May 17–22, 2026
📍 Sissi, Crete, Greece
Topics: cytokines & cell communication, inflammation and cancer, #tumormicroenvironment, #irAEs, and therapies.
Register: www.aegeanconferences.org/src/App/conf...
Weekly reads 23/2/26:
When context controls cancer: oxygen, space, niches and chromatin
open.substack.com/pub/behindth...
Cancer isn’t just mutations: it’s metabolism, space, niches, and chromatin.
#CancerResearch #SingleCell #SpatialBiology #TumorMicroenvironment #PrecisionOncology
🎉 Excited to share our cover article in Cancer Research!
We identified distinct tumor‑immune ecologies in lung cancer that predict immunotherapy response—moving beyond single biomarkers to spatial interactions. #CancerResearch #Immunotherapy #TumorMicroenvironment #Biomarkers
Paper: t.co/cLLk8JX4UH
CANCER METABOLISM REVIEW: Metabolic permissiveness: how tissue context shapes cancer
By Chrysanthi Moschandrea and Christian Frezza
➡️ https://genesdev.cshlp.org/content/40/5-6/287.full
Christian Frezza CECAD Cologne Universität zu Köln
#cancermetabolism #tumormicroenvironment
Last week, CSI Singapore hosted Prof. Hiroyoshi Nishikawa from National Cancer Center (NCC) Japan. He spoke on the topic “Immuno-genomic Analysis Elucidates Immunosuppressive Mechanisms in the Tumor Microenvironment”.
#tumormicroenvironment #cancerimmunology #Immunogenomics #cancerresearch
Using integrated #scRNAseq, #Immunofluorescence, and functional validation, this study shows that the #Immunosuppressive #TumorMicroenvironment contributes to tumor aggressiveness in lymphovascular invasion-positive #PDAC.
#OpenAccess: doi.org/10.1016/j.ge...
This review provides insights into #Epigenetic alterations in #Cancer and the #TumorMicroenvironment, outlining their roles in tumor progression and the therapeutic potential of epigenetic drugs and combination strategies.
#OpenAccess: doi.org/10.1016/j.ge...
New research has revealed that certain #nerves involved in the body’s “fight or flight” #StressResponse can support the growth of #PancreaticCancer.
#SympatheticNerves #TumorGrowth #TumorMicroenvironment
This #STTT study identified glycolytic heterogeneity within the #PDAC #TumorMicroenvironment and proposes a novel glycolysis-based framework for patient stratification to guide personalized medicine & #PrecisionOncology.
#OpenAccess: doi.org/10.1038/s413...
Thanks to Gertraud Orend for a great #seminar today! Her talk highlighted that targeting tenascin-C in the #TumorMicroenvironment can improve #therapy responses.
#CancerResearch @3r-network-bw.bsky.social
The dysadherin/CA9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression.
Microenvironmental acidity as a driver of malignancy.
doi.org/10.1038/s413...
#ColorectalCancer #TumorMicroenvironment #CA9 #Dysadherin #TumorAcidity #CancerProgression
Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression.
Tumor–immune crosstalk meets cell death control.
doi.org/10.1038/s413...
#ColorectalCancer #TumorImmunology #Ferroptosis #TumorMicroenvironment
Graphical summary of SMLR1 in colorectal cancer liver metastasis. Primary colon tumor cells metastasize to the liver, where SMLR1 expression increases. SMLR1 interacts with macrophage receptors MRC1 (CD206) and SIGLEC1 (CD169), promoting macrophage polarization toward an immunosuppressive, pro-tumoral phenotype. The diagram highlights immune suppression and enhanced tumor growth within the liver-specific metastatic niche.
📖 Commentary Spotlight
In the inaugural issue, Liu discusses how SMLR1 reshapes the liver metastatic niche through macrophage polarization, highlighting its role in cancer plasticity and immune modulation.
🔗 www.pivotscipub.com/chp/1/1/0002...
#CancerHeterogeneity #TumorMicroenvironment
Graphical abstract illustrating colorectal cancer liver metastasis. Cancer cells in the colon metastasize to the liver, where they upregulate SMLR1. SMLR1 interacts with macrophage receptors MRC1 (CD206) and SIGLEC1 (CD169), promoting tumor–macrophage interactions within the liver microenvironment. Legend indicates cancer cells (green), macrophages (beige), and molecular interactions.
📘 CHP Archive Spotlight #02
Original Research (2024) | Wong et al.
📢 New mechanistic insight in CRC liver metastasis:
Cancer cells upregulate SMLR1 to engage immunosuppressive TAMs, reshaping the liver niche.
🔗 www.pivotscipub.com/chp/1/1/0003...
#ColorectalCancer #TumorMicroenvironment
#Hypoxia-driven antigen loss and #VEGF secretion drive resistance to MUC16-targeted BITEs in #OvarianCancer, while VEGF blockade restores #cytotoxicity, highlighting #TumorMicroenvironment targeting to boost BITE immunotherapy. @harvardmed.bsky.social
#STTT: doi.org/10.1038/s413...
Don't miss her talk!
🗓 When: June 28 – July 1, 2026
📍 Where: Salt Lake City, Utah
👉 Become a member & Save: metastasis-research.org/membership-a...
#MRS2026 #EvanthiaRoussosTorres #BreastCancer #Immunotherapy #TumorMicroenvironment #Metastasis #USC #WomenInScience
Created by Dr. Spencer Watson uses hyperplexed immunofluorescence data. This work shows how microscopy and computer vision can be combined to better understand complex cellular systems.
#sciart #microscopy #computervision #cancerbiology #tumormicroenvironment #immunofluorescence #artinscience
What if the extracellular matrix actively reprograms TGFβ signaling to drive metastasis?
Our new study reveals that the COMP–PMEPA1 axis promotes EMT and shifts signaling toward pSMAD1/5 in breast cancer cells.
🔗 doi.org/10.1002/1878...
#BreastCancer #EMT #CancerBiology #TumorMicroenvironment
🧬 Tumor Microenvironment — Jan 2026
• Engineered CAR-T and TAM targeting reshape local immunity
• Fibroblast checkpoints and macrophage signaling drive resistance
• DNA sensing and pyroptosis pathways amplify immunotherapy response
pir.sh/9XygJPXd3w
#TumorMicroenvironment #CancerImmunology #TAMs
This #STTT review outlines the advanced engineering and combination strategies for #OncolyticViruses to enhance their ability to selectively lyse #MalignantCells and reprogram the #TumorMicroenvironment for #SystemicImmunity.
#OpenAccess: doi.org/10.1038/s413...
🌐 Join @keystoneSymposia.bsky.social #TumorMicroenvironment: Drivers of Progression & #Resistance, this May in Whistler 🚠 JEM's @zhijuanjexpmed.bsky.social is attending!
Don't miss deadlines for abstract, scholarship, early reg 👉 www.keystonesymposia.org/conferences/...
#KSTumorMicro26
This review on #AngioimmunoblasticTcellLymphoma highlights #epigenetic dysregulation, signaling changes, #TumorMicroenvironment interplay, prognostic models, and evolving epigenetic therapies. @fudan-university.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
Weekly reads 2/2/26 :
How space, context, and uncertainty reshape cancer and single-cell biology
open.substack.com/pub/behindth...
Big theme: space + context + mechanism > black-box scale alone.
#SpatialOmics #SingleCell #CancerBiology #TumorMicroenvironment #AIinBiology #Immunology
A #PhotodynamicTherapy (PDT) platform inhibiting CCL5 shows efficient drug accumulation & disruption of the #Immunosuppressive #TumorMicroenvironment enhancing the therapeutic efficacy against #BreastCancer & #Melanoma.
#STTT #OpenAccess: doi.org/10.1038/s413...
This review shows how #MetabolicReprogramming drives #ColorectalCancer initiation, progression, resistance & recurrence, detailing #TumorMicroenvironment crosstalk and signaling, while highlighting metabolic #biomarkers for early diagnosis.
#OpenAccess: doi.org/10.1016/j.ge...
Abstract Submission, Travel Award Applications, and Early Fee Deadline Extended to February 28. Join us at the 7th Int'l Conference on #Cytokines in #Cancer www.aegeanconferences.org/src/App/conf... #Tumormicroenvironment #Protumorigenic #intercellular
🌍World Cancer Day | A new study from Cell reframes #cancer as a multidimensional system shaped by:
🔬Cancer cell traits
🧬Enabling characteristics
🧫The tumor microenvironment
🌐Whole-body influences
🧐Learn more: file.medchemexpress.com/pdf/MedChemE...
#WorldCancerDay #TumorMicroenvironment
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