#mTORPathway

Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

2 months ago

This review explores the #mTORpathway structure and its molecular regulation, highlighting the therapeutic potential of targeting mTOR in #ClinicalTrials and its critical interplay with mitochondrial function. @univparissaclay.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

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Genes & Diseases Journal

@genesndiseases.bsky.social

4 months ago

This review outlines recent progress in treating #DiabeticNephropathy via drugs and molecules targeting the #mTORpathway, offering insights for improved prevention and therapy. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

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Epilepsia Journal

@epilepsiajournal.bsky.social

7 months ago

Our findings suggest that everolimus is a promising precision therapy for NPRL2- and NPRL3-related epilepsy, with the potential to reduce seizure frequency, thereby improving patient quality of life.
doi.org/10.1111/epi....

#epilepsy #Epilepsia #ILAE #everolimus #GATOR1complex #mTORpathway

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Epilepsia Journal

@epilepsiajournal.bsky.social

1 year ago

Key point: Analysis of cortical samples from HMG patients reveals abnormal development of Pvalb interneurons, which acquire cytomegalic features.
doi.org/10.1111/epi....

#epilepsy #ILAE #corticaldevelopmentaldisorders #interneurons #mTORpathway #neocortex

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Genes & Diseases Journal

@genesndiseases.bsky.social

1 year ago

mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets

This bibliometric analysis discusses mTOR signaling-associated pathological mechanisms in various renal cell types within a #diabetic environment & highlights the therapeutic implications of targeting the #mTORpathway in #DiabeticNephropathy. #medsky

#OpenAccess: www.sciencedirect.co...