Latest posts tagged with #mdm2 on Bluesky
🔬February New Releases
🚀1,000+ new molecules for #Oncology, #Neurology, #Immunology, #Cardiovascular studies.
Key targets: #Hsp70, #MDM2, #EGFR/HER2, #M4, #Keap1-Nrf2, #IP6K. Includes first-in-class & clinical-stage compounds to boost #DrugDiscovery & #TargetValidation.
MDM2 inhibitors in cancer immunotherapy: Current status and perspective
An overview of MDM2’s role in regulating #CancerImmunotherapy, summarizing preclinical & clinical findings on #MDM2 inhibitors in combination with #Immunotherapy, and highlighting MDM2 inhibition as a therapeutic strategy.
#OpenAccess: doi.org/10.1016/j.ge...
This review explores #MYCN-driven #oncogenesis in #neuroblastoma, outlines emerging therapies, and highlights that dual targeting of MYCN and the #MDM2 #oncogene is a promising strategy for high-risk neuroblastoma and other #cancers. @uh.edu
#OpenAccess: doi.org/10.1016/j.ge...
📰New & Featured | November New Releases
🚀1,000+ New Bioactive Molecules, targeting #WEE1 #HPK1 #MDM2 #TRPA1 #PARK7 #GLP1R
✔Reduce trial-and-error in early discovery
✔Access phase-advanced, high-selectivity research tools
#Oncology #Neuroscience #DrugDiscovery #ResearchTools
This review from @uh.edu explores the oncogenic mechanisms of #MYCN, the therapeutic potential of targeting MYCN and #MDM2, and the promise of dual inhibition in treating #Neuroblastoma and other #Cancers. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
This review outlines how #MDM2 influences #ImmuneRegulation, #TumorImmuneEvasion, and #Hyperprogression, and shows that MDM2 inhibition may boost #Immunotherapy. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
A review on the role of #MDM2 in regulating the #ImmuneMicroenvironment, tumor #ImmuneEvasion, & hyperprogression during #immunotherapy, with insights on the application of MDM2 inhibitors in combination with immunotherapy in tumors with MDM2 overexpression. #medsky
www.sciencedirect.co...
☕️Fulcher et al. show that #MDM2 times mitosis through self-catalysed ubiquitination and proteasomal destruction, triggering G1 arrest following delays in #mitosis associated with chromosome instability and #aneuploidy.
bit.ly/3EXaAoN
"Cena zakupu metra kwadratowego nie mogła przekraczać określonych limitów obliczanych wg wzoru stanowiącego iloczyn powierzchni użytkowej mieszkania i średniego wskaźnika przeliczeniowego kosztu odtworzenia."
biznes.pap.pl/wiadomosci/f...
#nieruchomosci #mdm2 #mieszkaniedlamlodych2
MDM2 inhibitors restore p53 tumor-suppressor activity by blocking MDM2-p53 interaction, driving cancer cell apoptosis & growth arrest. Promising for cancers with wild-type p53, like AML & sarcomas, but challenges in toxicity. Research aims to optimize use. #MDM2 doi.org/10.1038/s414...
Dzisiejsze wydanie #bezkitu
Władysław Kosiniak Kamysz :
"Początek przyszłego roku musi minister Krzysztof Paszyk to ogłosić. Ja jestem zwolennikiem czegoś w stylu MDM 2.0."
#nieruchomosci #mieszkania #mieszkanie #nastart #kredytnastart #mieszkanienastart #kredyt0 #kredythipoteczny #polityka #mdm2
