#CircRNA

2 months ago

Uncover the roles of circular RNAs in gene regulation and disease with Novogene’s circRNA sequencing services. Gain precise insights into their expression and function.

Learn more: https://bit.ly/3P22IE7

#circRNA #CircularRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation

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CircAge: A Comprehensive Resource for Aging-associated Circular RNAs Across Species and Tissues Abstract. Circular RNAs (circRNAs) represent a novel class of RNA molecules characterized by a circular structure and enhanced stability. Emerging evidence

2 months ago

CircAge: A Comprehensive Resource for Aging-associated Circular RNAs Across Species and Tissues

#CircAge #circRNA #aging

"Approximately 23% of circRNAs exhibit sequence conservation across different species, ...warrant focused attention and in depth investigation"

academic.oup.com/gpb/article/...

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Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

3 months ago

Intranasal circRNA vaccination triggers strong T cell responses against lung cancer—highlighting a needle-free path for future immunotherapies.
#circRNA #LungCancer #TCellResponse #CancerVaccine #MucosalImmunity
www.nature.com/articles/s41...

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MedComm

@medcomm.bsky.social

3 months ago

#Article in #MedComm
circRNA-SORE/UBQLN1/GPX4 Mediates the Acquisition of Sorafenib Resistance in Hepatocellular Carcinoma Through Inhibition of Ferroptosis doi.org/10.1002/mco2...

#circRNA #ferroptosis #sorafenib #resistance #UBQLN1 #GPX4

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Thiard News@F4F

@newsen.bsky.social

3 months ago

Circular Genomics to Present Groundbreaking Blood Biomarkers for Alzheimer's Disease at CTAD 2025 Discover how Circular Genomics' innovative circular RNA biomarker platform is revolutionizing early detection of Alzheimer's Disease at CTAD 2025.

Circular Genomics to Present Groundbreaking Blood Biomarkers for Alzheimer's Disease at CTAD 2025 #United_States #San_Diego #Alzheimer's_Disease #Circular_Genomics #circRNA

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RNAConnect

@rnaconnect.bsky.social

4 months ago

[1/2] A new publication from Warkentin & Pyle presents a practical workflow for accurate circRNA detection using UltraMarathonRT® (uMRT), a highly processive reverse transcriptase.

Pub 🔗 in the comments.

#cDNA #RNA #RNAseq #circRNA #RTPCR #RNASky

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Molecular Therapy Family of Journals

6 months ago

Uncover the roles of circular RNAs in gene regulation and disease with Novogene’s circRNA sequencing services. Gain precise insights into their expression and function.

Learn more: bit.ly/3P22IE7

#circRNA #CircularRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation

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@moltherapy.bsky.social

6 months ago

The cover image shows pumpkin spice DNA. Formulation is a key component in the success of nucleic acid delivery. Sallah et al. investigated how the addition of cucurbit[n]urils (CBs) to cationic polymers altered the profile of DNA delivery, reducing inflammation but increasing expression. Image credit: John Tregoning, Charlotte Tregoning, and Sophie Tregoning.

The new issue of #MolecularTherapy Nucleic Acids is out now. This issue features original articles on replicon #RNA vaccination, #circRNA therapeutics, mRNA-encoded BiTE cancer therapy, and more. Read it today: http://dlvr.it/TMzM2n
#MTNA #ASGCT

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Genes & Development

@genesdev.bsky.social

6 months ago

RESEARCH PAPER: ELAV mediates circular RNA biogenesis in neurons
By Alfonso-Gonzalez et al.
➡️ https://tinyurl.com/gd352670

#circRNA #neuroscience #RNAbindingprotein #Drosophila #embryos #neurons #mRNA #introns #splicing

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Genes & Diseases Journal

@genesndiseases.bsky.social

7 months ago

This review details #circRNA biogenesis and their role in #HepatitisBvirus-induced #HepatocellularCarcinoma, highlighting therapeutic potential, past research advances, and current methodological challenges, offering insights to guide future investigations.

www.sciencedirect.com/science/arti...

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7 months ago

Direct circRNA-mRNA Binding Controls mRNA Fate "...novel & potentially transform. mech. of action: the direct interaction of #circRNAs w/mRNAs to regulate their fate. ...can influence mRNA stability & translation, ...new layer of post-transcriptional gene regulation." #circRNA

www.mdpi.com/3408568

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How automotive exec Crystal Brown founded CircNova, an AI drug discovery biotech | TechCrunch Tiny Michigan biotech startup CircNova has raised a $3.3 million seed round for its technology that uses AI to target "circular RNA." The development

7 months ago

This article filled me with hope, but circRNA isn't getting nearly enough attention or funding. techcrunch.com/2025/02/21/h... #circRNA #biotech #disease #cancer #aging

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Thiard News@F4F

@newsen.bsky.social

8 months ago

Circular Genomics Strengthens Its Leadership with New Commercial Advisory Board for Neurology Innovations Circular Genomics has formed a new Commercial Advisory Board to bolster its precision medicine initiatives in neurology and psychiatry. This strategic move aims to enhance market access and patient care.

Circular Genomics Strengthens Its Leadership with New Commercial Advisory Board for Neurology Innovations #USA #San_Diego #Advisory_Board #Circular_Genomics #circRNA

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9 months ago

Uncover the roles of circular RNAs in gene regulation and disease with Novogene’s circRNA sequencing services. Gain precise insights into their expression and function.

Learn more: bit.ly/3P22IE7

#circRNA #CircularRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation

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@monikapiwecka.bsky.social

9 months ago

Cool 😎

#DIS3 #Exosome #Independent
#circRNA #RNADegradation
#RNA #RNAsky

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Monika Piwecka

9 months ago

Cytoplasmic DIS3 is an exosome-independent endoribonuclease with catalytic activity toward circular RNAs CircRNAs are generated during splicing, but their specific degradation pathways are poorly understood. Latini et al. identify and biochemically characterize the exo- and endoribonuclease DIS3 as a can...

#RNAsky #circRNA
...and more about DIS3...

www.cell.com/cell-reports...

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9 months ago

Nice keynote by Ling-Ling Chen: #DIS3 and #circRNA #Degradation
#RNA25

www.cell.com/molecular-ce...

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10 months ago

Uncover the roles of circular RNAs in gene regulation and disease with Novogene’s circRNA sequencing services. Gain precise insights into their expression and function.

Learn more: bit.ly/3P22IE7

#circRNA #CircularRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation

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11 months ago

Research conditions in the USA. #circRNA #aging #cancer #NIH

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Circular RNAs: An emerging precise weapon for diabetic nephropathy diagnosis and therapy Diabetic nephropathy (DN) is a prevalent chronic microvascular complication associated with diabetes mellitus and represents a major cause of chronic …

11 months ago

"..studies have shown that #circRNA is closely related to the growth and development of organisms, disease occurrence and development, and it is predicted to be closely related to disease diagnostic markers, but its biological function is still largely unknown." www.sciencedirect.com/science/arti...

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Circularized RNA as novel therapeutics in cancer Circular RNAs (CircRNAs) regulate gene expression by functioning as microRNA sponges, regulating protein stability, and gilding proteins for gene tran…

11 months ago

Circularized RNA as novel therapeutics in cancer www.sciencedirect.com/science/arti... #cancer #aging #circRNA #geneexpression #microRNA #sponges

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Tobias Jakobi

@tobias.jako.bi

1 year ago

Postdoctoral Research Associate I, Translational Cardiovascular Research Center (Phoenix) Develop and maintain detailed records of experiments, analyzing and writing findings.Assist with preparation of grants and manuscripts.Present manuscr...

Calling all #compbio postdocs! 🧠🧬 Join our team at the Jakobilab & develop cutting-edge software for understanding non-coding RNA (especially circRNAs) in #heartdisease. Postdoc position available - apply now! arizona.csod.com/ux/ats/caree... #sciencejobs #openpositions #circRNA #bioinformatics

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Degradation of circular RNA by the ribonuclease DIS3 Features of circular RNAs (circRNAs) produced by back-splicing of eukaryotic exon(s) make them resistant to degradation by linear RNA decay machinerie…

1 year ago

DIS is interesting!
#circRNA #Degradation #DIS3 #Ribonuclease #RNAExosome

www.sciencedirect.com/science/arti...

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Tobias Jakobi

@tobias.jako.bi

1 year ago

gROUNDbreaking approaches for advancing circRNA research: detection, function, therapeutics Circular RNAs (CircRNAs) are a rediscovered class of RNA species that originate from back-splicing events, which have been reported across all domains of life. Many circRNAs are stable, abundant and …

Registration is now open for the #EMBO practical workshop dedicated to Circular RNAs: gROUNDbreaking approaches for advancing #circRNA research: detection, function, therapeutics, to be held from 31 May to 6 June 2025 at the University of #Trento, Italy!

meetings.embo.org/event/25-cir....

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