Latest posts tagged with #KINASE on Bluesky
Modification of PLK1 following the surface-entropy reduction approach yielded a protein which crystallizes readily and forms an excellent new crystallization platform for PLK1–inhibitor co-crystal structures #SurfaceEntropyReduction #SER #Kinase doi.org/10.1107/S205...
RESEARCH PAPER: Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3
By Ji et al., and Feng Cong
➡️ https://genesdev.cshlp.org/content/40/1-2/56.abstract
#development #signaling #kinase #WNT
#MERANTI #MENGKAI
allgraph.ro/advanced-sea...
#TIMIDINA #KINASE
aepiot.ro/advanced-sea...
#MANJALARA
multi-search-tag-explorer.headlines-world.com/advanced-sea...
allgraph.ro
The combined action of #TKIs on #thyroid gland function & peripheral deiodinases generates a unique phenotype of primary #hypothyroidism characterised by increased TSH concentrations & a reduced T3 to T4 ratio www.thelancet.com/journals/lan...
#tyrosine #kinase #inhibitors #thyroidcancer
#EndoSky
William J. Evans of @ucberkeleyofficial.bsky.social et al. observed the effects of inhibition of Janus #kinase signalling during controlled mechanical #ventilation on the rate of skeletal muscle protein synthesis in this recent study🔎 🧪
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
Newly discovered host mechanism in #coronaviruses ...
| #virus | #kinase | #microscopy | #infections | Via eurekalert .org
Meetup with Jim @jwoodgett.bsky.social at @ccralliance.bsky.social conference in Calgary #CCRC2025 Always fun when two kinase scientists get together to discuss research. The conversation was definitely active 🧫🔬⚗️
#ScienceIsFun #Kinase #CancerResearch @terryfoxresearch.bsky.social
we just posted our new work on #SRC #kinase led by the superb Prashant Jain 🤩 Inspired by nature, we discover that the length of the catalytic loop and the autophosphorylation site can be engineered to fine-tune downstream pathway activation. 🙏🏻 @oistedu.bsky.social
www.biorxiv.org/content/10.1...
genomirx.com/promega-her2... Promega HER2 Kinase Enzyme System, 1mg baculovirus in Sf9 GST tag @promegacorporation.bsky.social #her2 #kinase #enzyme #baculovirus #sf9 #gst @BPSBioscience @sigmaaldrich.bsky.social @prospec @mybiosource @chemiverseca.bsky.social
The 5th Virtual #ChemBioTalks continue with an insightful talk by @kellychibale.bsky.social. He talked about his group's research into new treatments for #malaria. Great insights into the repurposing of anti #cancer #kinase inhibitors to treat P. falciparum. onlinelibrary.wiley.com/doi/10.1002/...
Who knew the kinome has a dark side? To find out more- check out this new paper from our NSF Biofoundry. #glycotime #kinase 🧪
The Kannan Lab at UGA, with BioF:GREAT, has shown that the “dark kinome” still hides secrets 🔦 Enter DCLK3—a kinase with neuroprotective potential. We found it self-regulates in a brand-new way, and tags Tau as a substrate. A fresh spark for neurodegenerative research! 🧪
#BioFGREAT #NSF #kinase
Kinases contribute to regulation of cellular signalling and drive many diseases when dysregulated. Small molecule kinase inhibitors allow precise control over these enzymes, enabling pathway dissection, biomarker discovery and therapeutic targeting.🧪
#Kinase #MedChem
fluorochem.co.uk/product-cate...
Drs Jessica Home & Christopher Goodman highlight Nathanael Gray @elizabethwinzeler.bsky.social Debopam Chakrabarti & colleagues’ @cp-cellchembiol.bsky.social article on a #kinase #inhibitor's elusive #antimalarial #modeofaction. #haemoglobin #digestion
authors.elsevier.com/a/1ldhr5Eb1x...
More 🌽🌽 research—Mingliang Xu from China Agricultural University on quantitative resistance in #maize, and the calcium-dependent protein #kinase #QTL
Very much looking forward to the talk by @kellychibale.bsky.social at the 5th Virtual @chembiotalks.bsky.social and to learn more about the repurposing of #anticancer #kinase inhibitors to treat #malaria.
#ChemBio #ChemSky #DrugDiscovery
Want to know which kinase phosphorylates your site of interest in cells, go to kipik.dundee.ac.uk. The patented KiPIK screening method developed in Jon Higgins’ group @medicalsciencesncl.bsky.social is now available as a new service from @mrcppu.bsky.social in Dundee. #kinase #molbiol #chembiol.
3 projects by the LED3 researchers Nathaniel Martin, Anthe Janssen and Mirjam Huizenga have been awarded NWO Take-off funding to explore commercial development of compounds and technologies with applications in #oncology, #NeuropathicPain treatment and #kinase research!
www.nwo.nl/en/news/49-t...
Came across this #kinase work, very cool for where in trials the compound is. Interesting commentary noting AI focus on #allosteric sites (notoriously hard to model de novo) although truthfully traditional type I cmpds were extended into a back pocket, so not type III #medchem
rdcu.be/ev0b6
New review out with @jburkevic.bsky.social!
We highlight recent advances in our understanding of the role the phosphoinositide PIP3 plays in regulating the protein kinases Akt, PDK1, and BTK from a structural perspective.
#kinase #phosphoinositides
portlandpress.com/biochemsoctr...
Accelerate kinase research with bioluminescent assays: ADP-Glo™, NanoBRET® TE, Lumit® & HiBiT.
Measure activity, affinity, signalling and degradation with ease
👉 www.promega.co.uk/applications/small-molec...
#kinase #bioluminescent #assays
SciTech Chronicles. . . . . . . . .May 8th, 2025
bit.ly/stc050825
#SIK3 #NSS #profile #kinase #pathogens #intercontinental #balloons #"35 kilometers" #"jurema preta" #dimethyltryptamine #"no ban" #"Mimosa tenuiflora" #TYK2 #psoriasis #inhibitor #Friendship #"Lamprotornis superbus" #reciprocal #DNA
SciTech Chronicles. . . . . . . . .May 6th, 2025
bit.ly/stc050625
#EphB1/2 #tyrosine #kinase #inhibitors #carbene #thiamine #B1 #3D-printable #electroencephalogram #continuously #bioadhesive #AMT #mesothelioma #"low-carbon metal oxides" #CO2 #"digital twin" #"3D digital model" #sonar #Magellan
Faster #kinase research is here! 🧪 Our new curated @SignalChem kinase bundles simplify selection & boost discovery. Explore target family-based kits & accelerate your work: ow.ly/SJgl50VLFRz
💊 Tyrosine kinases have an inevitable role in the proliferation of #tumour cells, hence, #tyrosine #kinase inhibitors are frequently employed as #anti-neoplastic agents in the treatment of #colon, #breast, #kidney, and #lung #cancers
💻 www.thieme-connect.de/products/ejo...
#PcLRR-RK3, an #LRR #receptor #kinase is required for growth and in-planta infection processes in #Phytophthora capsici
doi.org/10.1080/2150...
@tandfresearch.bsky.social
The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio
Dr. Jared Johnson, a scientist at Dana-Farber & instructor at Harvard, explores #kinase signaling in #cancer & metabolism. He collaborates with Cell Signaling Technology to share findings with the scientific community.
Register for our symposium on 2/19👉 ow.ly/lRR950UHhyl
Meet Dr. Earl May, Senior Director at @assayquant, in our Speaker Spotlight Series! A leader in #kinase drug discovery with a PhD from Yale, Dr. May has driven breakthroughs in #biochemistry and #enzymology.
📅 Join the Cell Signaling Symposium on Feb 19: ow.ly/JpuM50UCN3y
