#MYC

@cancergrand.bsky.social

1 month ago

Scientists may have found key to treating hidden cancer growths Researchers say the findings offer a promising way to improve existing cancer therapies as well as develop new ones

Read about #CancerGrandChallenges Team #KOODAC’s innovative study, featured this week in @the-independent.com 👇
🔗 independent.co.uk/news/health/...

Funded through @cancergrand.bsky.social l by @cancerresearchuk.org , @institut-cancer.bsky.social & #Kika.

#CancerResearch #ImmunoOncology #MYC

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@lsouceklab.bsky.social

1 month ago

Frontiers | MYC at the tumor–immune interface: mechanisms of immune escape and immunotherapy resistance Immunotherapies have transformed cancer treatment by harnessing the immune system to recognize and eliminate malignant cells, offering durable clinical benef...

New review just out in Frontiers in Immunology! 🎉

We dive into how #MYC reshapes the tumor–immune interface to drive #immuneescape and resistance to #immunotherapy.
Open access here 👉 www.frontiersin.org/journals/imm...
@vhio.bsky.social @icreacommunity.bsky.social #peptomyc

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@lsoucek.bsky.social

1 month ago

Frontiers | MYC at the tumor–immune interface: mechanisms of immune escape and immunotherapy resistance Immunotherapies have transformed cancer treatment by harnessing the immune system to recognize and eliminate malignant cells, offering durable clinical benef...

New review just out in Frontiers in Immunology! 🎉

We dive into how #MYC reshapes the tumor–immune interface to drive #immuneescape and resistance to #immunotherapy.
Open access here 👉 www.frontiersin.org/journals/imm...
@vhio.bsky.social @icreacommunity.bsky.social @lsouceklab.bsky.social #peptomyc

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Julius-Maximilians-Universität Würzburg

@uni-wuerzburg.de

1 month ago

The authors of the Cell publication (from left to right): Martin Eilers, Amel Aziba, Leonie Uhl and Sinah Löbbert.

New Paper out in @cellpress.bsky.social: How cancer cells protect themselves from the immune system. Cancer gene #MYC camouflages tumours by suppressing alarm signals. ‪@mycgyvers.bsky.social @cancergrand.bsky.social ‬‬‬‬ 📷 Daniel Peter
➡️ www.uni-wuerzburg.de/en/news-and-...

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Cancer Grand Challenges

@cancergrand.bsky.social

1 month ago

Overcoming immune evasion in solid tumours New findings from team KOODAC

Team #KOODAC ’s first @cellpress.bsky.social paper uncovers how MYC helps solid tumours evade immune detection—revealing a new model with major implications for immunotherapy.

Read the story behind the science
👇
Q&A: shorturl.at/7FXUw
Paper: shorturl.at/DYuWO

#CancerResearch #ImmunoOncology #MYC

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@lsoucek.bsky.social

1 month ago

SF was home for 10 years, and UCSF is where I trained and grew as a scientist. Grateful to bridge academia and biotech, past and present. #MYC #OMO103 #Biotech #TranslationalResearch

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@lsoucek.bsky.social

2 months ago

Frontiers | The leading role of MYC in DNA damage response: exploring opportunities for therapeutic inhibition MYC performs a dual role in DNA Damage Response (DDR), promoting genomic instability through replication stress, R-loop formation, and topoisomerase-mediated...

Really happy to share our new open-access review in Frontiers in Cell and Developmental Biology 🎉
#MYC inhibition creates vulnerabilities that can be targeted with #DDR inhibitors.
@vhio.bsky.social @icreacommunity.bsky.social #peptomyc @lsouceklab.bsky.social
www.frontiersin.org/journals/cel...

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@advbiores.bsky.social

2 months ago

Evaluation of Myc Oncogene Expression in Human Breast Cancer and Its Relationship With Acsl4 and Lipin-1 Expression MYC expression is higher in breast cancer and correlates with tumor size and stage, but not directly with lipid metabolism enzymes. #BreastCancer #MYC

MYC expression is higher in breast cancer and correlates with tumor size and stage, but not directly with lipid metabolism enzymes. #BreastCancer #MYC
www.rimpacts.com/rd/p?c=10118... 📄DOI: doi.org/10.4103/abr....

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Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

2 months ago

Limited SUMOylation inhibitor administration enhances eradication of Burkitt’s lymphoma with CD19 CAR-T therapy - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Limited SUMOylation inhibitor administration enhances eradication of Burkitt’s lymphoma with CD19 CAR-T therapy

This letter reports that the #SUMOylation inhibitor TAK‑981 downregulates #MYC, induces #apoptosis, and enhances CD19 CAR‑T efficacy in #BurkittsLymphoma, highlighting SUMOylation inhibition as a promising adjunct strategy.

#OpenAccess in #STTT: doi.org/10.1038/s413...

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Leiden Early Drug Discovery & Development (LED3)

@led3hub.bsky.social

2 months ago

ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors Protein therapeutics have transformed drug discovery by enabling modulation of challenging targets inaccessible to small molecules. However, most prot…

New Publication from our LED3 hub!

The group of @sebastianpomplun.bsky.social published "ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors" in the journal Chem.

www.sciencedirect.com/science/arti...

#ChemSky #ChemBio #DrugDiscovery #MYC #Cancer

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@lsoucek.bsky.social

3 months ago

Honored to deliver a keynote today at the 19th Scientific Day & 29th Annual Conference of Vall d’Hebron on collaborative, challenge-driven research with transformative health impact. #MYC #OMO-103 #Omomyc
@vhio.bsky.social @icreacommunity.bsky.social #peptomyc

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Andros 📷 NYC

@nyandreas.bsky.social

4 months ago

Midtown Manhattan view from the Edge, at Hudson Yards, New York City

Midtown Manhattan, New York City

#photography #newyork #city #skyline #skyscraper #architecture #manhattan, #myc #bigapple #travel #hudsonyards #sunset

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Parc Científic de Barcelona

@www.pcb.ub.edu

4 months ago

#PCBCommunity |🧬 El @cnag-eu.bsky.social revela el paper del gen #MYC en la progressió agressiva de la #leucèmia linfocítica crònica.🔬 Les troballes ofereixen noves perspectives sobre quins pacients tenen més risc i apunta cap a possibles estratègies de #tractament personalitzat.

👉 tuit.cat/UrD2b

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Vall d’Hebron Institute of Oncology

@vhio.bsky.social

7 months ago

🔝 Esta semana hemos sabido que @LauraSoucek recibe la subvención #ProofOfConcept de @erc.europa.eu para el proyecto #SONOMYC.

👏 Enhorabuena ‼️

➡️ https://linke.to/ERCLauraSoucek_VHIOCAST

#ERCPoC #MYC

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Vall d’Hebron Institute of Oncology

@vhio.bsky.social

8 months ago

Congrats to Laura Soucek for receiving the @erc.europa.eu #ProofOfConcept grant for #SONOMYC ‼️

🎯 The project aims to optimize the delivery of the #MYC inhibitor Omomyc to the brain to treat brain tumors & metastases 👉 https://linke.to/ERCLauraSoucek_VHIO

#ERCPoC.

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Cancer Survivors Club 📙

@thecancersurvivorsclub.com

9 months ago

World-first "undruggable" cancer treatment enters human trial A promising new treatment to combat "undruggable" cancers has been green-lit for a human trial in 2025. It's hoped the novel drug will be able to stunt the growth and enable the effective treatment of...

🚀 World-first “undruggable” cancer therapy heads to human trials in 2025! Targeting the notorious MYC oncogene, this could finally corner some of cancer’s slipperiest villains. Watch this space. 🔬✨ #CancerResearch #MYC #TCSC #Oncology #ClinicalTrials

newatlas.com/cancer/mca-c...

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Krzysztof Herka

@kherka.bsky.social

9 months ago

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Inserting an unrelated G4 structure (Pu27 from the #Myc promoter - as featured in @isabelesain.bsky.social's brilliant work www.pnas.org/doi/abs/10.1...) recovers original globin expression and enhancer function (Figure 3D) 5/9

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wunby

@jabberfoxy.bsky.social

9 months ago

#myc #brill

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Stem Cell Reports

@stemcellreports.bsky.social

9 months ago

New study shows cell competition eliminates #aneuploid human pluripotent #stem cells in diploid-aneuploid mosaic populations. #MYC and #p53 levels determine competitive ability of hPSCs. ow.ly/eiuu50W19as

@isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social

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サードニュース@相互フォロー100%

@new3rd.bsky.social

9 months ago

白血病の悪化に関する新たな酵素の発見と治療の可能性 白血病の悪化に関与する新たな酵素SETD1Bを発見。MYC発現を制御する仕組みを解明し、治療の展望も期待される。新バイオマーカーの可能性についても考察。

白血病の悪化に関する新たな酵素の発見と治療の可能性 #千葉県 #千葉市 #白血病 #酵素 #MYC

白血病の悪化に関与する新たな酵素SETD1Bを発見。MYC発現を制御する仕組みを解明し、治療の展望も期待される。新バイオマーカーの可能性についても考察。

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Zeliel

@zelieldraws.bsky.social

9 months ago

The pump was down so Reagan’s been doing her best. Comm by @twatinthehat.bsky.social #Myc #Reaganridley #InsideJobNsfw

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iScience

@cp-iscience.bsky.social

9 months ago

Can targeting #SUMOylation open new doors in #OvarianCancer treatment? 🔍🧬

New #iScience study screened 30 patient-derived models — finding #MYC sensitivity & #ABCB1 resistance. A step toward #PersonalisedMedicine 💡

🧾 www.sciencedirect.com/science/arti...

#CancerResearch #TargetedTherapy #Drug

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Curvy Chubby Sexy Girls & Women

@curvychubbysexygw.bsky.social

10 months ago

www.threads.com/@thckgurl Sezy legs on your shoulders soon #explore #explorepage #myc #nyc

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Genes & Diseases Journal

@genesndiseases.bsky.social

10 months ago

Targeting MYC: Multidimensional regulation and therapeutic strategies in oncology

This review delineates the multifaceted roles of #MYC in #cancer progression, highlighting a spectrum of therapeutic strategies and inhibitors for #CancerTherapy that target MYC, either directly or indirectly. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

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🅱🅸🅶🅾🆁🆁🅴.🅾🆁🅶

@bigorre-org.mastodon.social.ap.brid.gy

10 months ago

Escuela Mariscal Sucre airport in Maracay (Venezuela) aviation weather and informations SVBS MYC Aviation weather with TAF and METAR, Maps, hotels and aeronautical information for Escuela Mariscal Sucre airport in Maracay (Venezuela)

Aviation weather for Escuela Mariscal Sucre airport in Maracay area (Venezuela) is “SVBS 302303Z AUTO NIL” : See what it means on https://www.bigorre.org/aero/meteo/svbs/en #maracay #venezuela #escuelamariscalsucreairport #svbs #myc #metar #aviation #aviationweather vl

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🅱🅸🅶🅾🆁🆁🅴.🅾🆁🅶

@bigorre-org.mastodon.social.ap.brid.gy

10 months ago

Escuela Mariscal Sucre airport in Maracay (Venezuela) aviation weather and informations SVBS MYC Aviation weather with TAF and METAR, Maps, hotels and aeronautical information for Escuela Mariscal Sucre airport in Maracay (Venezuela)

Aviation weather for Escuela Mariscal Sucre airport in Maracay area (Venezuela) is “SVBS 301103Z AUTO NIL” : See what it means on https://www.bigorre.org/aero/meteo/svbs/en #maracay #venezuela #escuelamariscalsucreairport #svbs #myc #metar #aviation #aviationweather vl

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Biozentrum, University of Basel

@biozentrum.unibas.ch

11 months ago

New insights challenge previous views about a muscle growth factor The protein Myc has long been thought to support skeletal muscle growth. Prof. Markus Rüegg's team at the Biozentrum provides compelling evidence that Myc in muscle fibers is dispensable for muscle gr...

New study by @ruegglab.bsky.social challenges previous view about the muscle growth factor #Myc! The protein is dispensable for #musclegrowth. High Myc levels disrupt muscle fiber structure & function. @unibas.ch @snsf-ch.bsky.social @naturecomms.bsky.social www.biozentrum.unibas.ch/news/detail/...

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