Severe acute respiratory syndrome coronavirus 2 infection and COVID-19 could potentially lead to new onset or relapse of glomerular disease via several mechanisms that could result in direct or indirect damage to the kidney, including inflammation, tissue hypoperfusion, endothelial dysfunction, vascular injury, thrombotic microangiopathy, dysregulation of the coagulation cascade, complement dysregulation and podocyte injury. IgG, immunoglobulin G.
- Endothelial damage: 🦠 can injure the cells lining BVs, leading to the formation of #microclots that obstruct blood flow within the kidneys. This lack of oxygen & nutrients can cause permanent tissue damage .
- Autoimmune response: An uncontrolled or misdirected immune response