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Posts tagged #PTMS

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Sialic Acid Linkage Identification in Glycosylated Peptides Using Multitandem Collision-Induced and Electronically Excited Dissociation Mass Spectrometry In our previous publication [Anal. Chem. 2023, 95, 7458–7467], we demonstrated the use of electron capture dissociation for Sa linkage analysis in N-glycans; however, its application was challenging b...

Incredible work just published yesterday using the ZenoTOF 7600
@sciex.bsky.social #Glycosylation #PTMs
pubs.acs.org/doi/10.1021/...

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#onsite (onsite.quantms.org) – phosphorylation site scoring

- Multiple algorithms: #PhosphoRS, #AScore, #Luciphor
- Advanced localization & confidence assessment using pAla method from @andrewrobertjones.bsky.social group
- Reliable PTM interpretation at scale

#phosphoproteomics #PTMs #proteomics

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Q&A: Matthias Mann on History, Future Potential of Proteomics The proteomics pioneer notes that the field has made tremendous technological strides over the decades but its clinical impact remains muted.

Interesting interview with Matthias Mann @mannlab.bsky.social. He talks about the big advances of proteomics and his outlook for the future. Great to see him highlight the unique potential of proteomics to detect protein modifications.
www.genomeweb.com/proteomics-p...
#Chemsky #MS #ChemBio #PTMs

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📢 Call for papers! 🧬🖥️🦠🧪🔬🥼
📖 Special Issue: Clinical Proteomics: Unravelling Drug and Disease Mechanisms (Fifth Edition)
✍ Edited by: Dr. Vikram Sharma
📅 Submission Deadline: 30 June 2026

🔗 www.mdpi.com/journal/prot...

#proteomes #proteomics #proteoform #MassSpec #drugs #clinical #PTMs

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Enhancing glycopeptide annotation and glycan localization using electron activated dissociation through a multiplexed parallel reaction monitoring design of experiments We present an optimized electron activated dissociation (EAD) methodology, based on hot electron capture dissociation, for liquid chromatography-tande…

Fantastic paper showcasing the power of EAD for glycopeptide annotation and glycan localization #ZenoTOF @sciex.bsky.social #PTMs
www.sciencedirect.com/science/arti...

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Integrative multi-layer workflow for quantitative analysis of post-translational modifications Novel algorithms based on ultratolerant database searching have paved the way for comprehensive analysis of all possible post-translational modifications (PTM) that can be detected by mass spectrometr...

🚨 New preprint from @cnicproteomics (CNIC - National Center of Cardiovascular Research, Madrid, Spain) 🚨

📄 Devesa et al. 2025
doi.org/10.1101/2025.01.20.633864

#Proteomics #PTMs #MassSpectrometry #Bioinformatics #OpenSearch #CNICproteomics #Cardiovasculardeseases

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PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease Recent discoveries reveal that post-translational modifications (PTMs) do more than regulate protein activity – they encode conformational states that…

🚨Publication alert! The final version of our cover feature article is OUT NOW in @cp-trendsbiochem.bsky.social

Read how we connect the #epichaperome with the #chaperone code.

#PTMs #HSP90 #PPI #neuroscience #NetworkBiology
Check out the review article here: www.sciencedirect.com/science/arti...

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When Modifications Rewrite Networks: How PTMs Reprogram Chaperones into Epichaperomes

Dive deeper into our @cp-trendsbiochem.bsky.social cover article! Read more on @springernature.com Communities:
communities.springernature.com/posts/when-m...
#Epichaperome #PTMs #NetworkBiology #SystemsBiology #TrendsBiochem #NatureCommunities

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The result? It provided the first detailed map of PTM dynamics in the heart and initial evidence for the accumulation of oxidative PTMs after chemotherapy.

#Proteomics #PTMs #SEBBM2025 #MassSpectrometry #CNICproteomics #Cardiovasculardeseases

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We are pleased to collaborate with researchers, clinicians, and industry partners who share our passion for unraveling the whole proteome.

Stay tuned for updates, publications, and opportunities to engage with our team

#Proteomics #MassSpectrometry #OpenSearch #PTMs #CNICproteomics

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🪱The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures

🔗https://buff.ly/3HWEtDM

@spanglab.bsky.social

#Celegans #Phosphatases #Spermatogenesis #PTMs

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🌟Very excited to share that our article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' is out online now in @cp-trendsbiochem.bsky.social
#PTMs #HSP90 #epichaperome #PPI #neuroscience @mskcancercenter.bsky.social
doi.org/10.1016/j.ti...

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As a valued BILLIEver, we’re inviting you to embark on an exclusive… As a valued BILLIEver, we’re inviting you to embark on an exclusive journey with us as we develop BILLIE—our groundbreaking new platform poised to redefine protein analysis. Through a dedicated…

Peptide mapping is vital for protein characterization but is often slow, complex, and incomplete. Our #PAMAF approach delivers 100% sequence coverage in just 20 mins, resolves isobaric peptides, and detects tough #PTMs. Become a BILLIEver to learn more:

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Where a PTM occurs can be as important as what it is. At #ASMS2025, Prof. Birgit Schilling’s team at
@buckinstitute.org used #PAMAF to resolve succinylation isomers on Atp5pf, revealing site-specific regulation critical to mitochondrial biology.

#Proteomics #PTMs @birgitschilling.bsky.social ‬

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February 24th 2020 ➡️ June 30 2025

My PhD has finally been conferred. 5 years of my life has finally been capped off with a certificate.

COVID, supervisors moving away, a shrinking lab, machines breaking, lab flooding, broken growth rooms and we're done.

#phd #ubiquitin #arabidopsis #wheat #PTMs

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#PTMS Princess tiny meat syndrome permeates ICE.

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Very happy to share that you can now read one of the works that was part of my PhD, available on @mhr-reprodsci.bsky.social ! #protamines #proteoforms #PTMs #exposome #aging

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Exciting talk by Max Kloet from the group of Gerbrand van der Heden van Noort from the LUMC at the #LED3Symposium. He talked about his research into the interplay of the posttranslational modifications of ubiquitination and ADP-ribosylation. www.biorxiv.org/content/10.1...

#PTMs #ChemBio

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What European defense is really looking for: Risk reduction and domestic continuity - Breaking Defense The key is not just building domestic defense industrial bases, but ensuring they also contribute meaningfully to the global supply chain.

European defense seeks risk reduction & domestic continuity! We spoke with Mike Vallillo, VP at Aerospace.Honeywell.com, on supporting supply chain continuity in Europe & Australia. Read more: breakingdefense.com/2025/06/what...

#SupplyChain #F35 #PTMS #sponsored

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We of course couldn’t let that slip and developed a method:
✅ compatible with tandem MS
✅ strong enrichment efficiency
✅ uses commercial reagents, works in tubes + 96-well plates
We hope it becomes your new favorite for hunting this tiny PTM 🔥
#citrullination #proteomics #ptms

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Our Motif-Specific mAbs...
✔ Motif-specific (and sensitive)
✔ Minimal homocitrullination cross-reactivity
✔ Works in real samples
Also? Some commercial Abs didn’t stand a chance. 😉
To try? We’re making ours openly available to support the citrullination community!
#Citrullination #Antibodies #PTMs

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The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio

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Tubulin tyrosination/detyrosination regulate the affinity and sorting of intraflagellar transport trains on axonemal microtubule doublets - Nature Communications Cilia assembly relies on cargo trains that move bidirectionally on separate tubules of the ciliary microtubular structure, preventing traffic jams. Here, the authors demonstrate that train sorting is ...

Loving this study by @gaiapigino.bsky.social and @stefandiezlab.bsky.social on the function of tubulin tyrosination. #PTMs #microtubules #cilia
www.nature.com/articles/s41...
You should also check out the related preprint by @ichikawa-lab.bsky.social on bioRxiv.

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Integrative multi-layer workflow for quantitative analysis of post-translational modifications Novel algorithms based on ultratolerant database searching have paved the way for comprehensive analysis of all possible post-translational modifications (PTM) that can be detected by mass spectrometr...

📢 Check out our latest work! A revolutionary #Bioinformatics tool for analyzing Post-Translational Modifications #PTMs.
Take your #Proteomics research to the next level with this new software from the Jesús Vázquez lab at CNIC.
www.biorxiv.org/content/10.1...

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Acknowledgement slide of Olivier Mercey's lab, collaborators and funders showing ultra expansion microscopy images of mouse photoreceptor connecting cilia.

Acknowledgement slide of Olivier Mercey's lab, collaborators and funders showing ultra expansion microscopy images of mouse photoreceptor connecting cilia.

Our 50th @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium kicked off with #UExM masterclass! Mysteries & hierarchies of #tubulin #PTMs in #ConnectingCilium #Bulge #IRDs- Olivier Mercey @centriolelab.bsky.social www.embopress.org/doi/full/10.... #ukcilia2025 /1

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Mechanisms of metabolism-coupled protein modifications This Perspective highlights how metabolic states regulate diverse protein modifications that affect physiology. In addition, the roles of subcellular localization of metabolic enzymes and the importance...

Discover how #metabolism shapes protein #PTMs! Unveil the intricate dance of modifications & feedback loops that regulate cellular functions. Dive into the 'modification of a modification' phenomenon! #science PMID:39775169, Nat Chem Biol 2025, @nchembio

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Exciting times in brain calcification research! Check out our Spotlight commentary in @cp-trendsmolecmed.bsky.social
Find it here: authors.elsevier.com/sd/article/S...
Keywords: #astrocyte #diseasemechanisms #membraneproteins #PTMs #neurovascular #neurodegeneration #dementia #brain #aging #newPI

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Pervasive phosphorylation by phage T7 kinase disarms bacterial defenses Bacteria and bacteriophages are in a constant arms race to develop bacterial defense and phage counter-defense systems. Currently known phage counter-defense systems are specific to (the activity of) ...

11/11 - Thanks to all involved - what a super collaboration! Savitski lab and @typaslab.bsky.social @embl.org with @alessioyang.bsky.social, @mgalactus.bsky.social / #phage #proteomics #phosphorylation #microbiology #PTMs

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Dear Mr. Lucas, thanks for programming Les Mis for Chorus when I attended Peter’s Township Middle School. I’ve had “Do You Hear the People Sing” stuck in my head!

#music #education #teachers #learning #doyouhearthepeoplesing #ptms #peterstownship #lesmis

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🧪 New tools are uncovering "zero-dalton" PTMs like D-amino acids (DAACPs) & isoaspartate (IACPs), crucial for peptide stability, aging, & disease. Advances in MS, IMS & bioinformatics boost detection despite no mass shift. A leap for proteomics! 🌟 #MassSpec #Proteomics #PTMs
doi.org/10.1002/mas....

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