#brca1

1 week ago

Illustration of three pink ribbons with text: “Triple-negative breast cancer* can be a hereditary cancer red flag! * Breast cancer with no estrogen, progesterone, or HER2 receptors on the tumor. Learn more at www.genetionary.org.”

Inherited mutations in BARD1, BRCA1, BRCA2, PALB2, and RAD51D genes are linked to an increased risk for TNBC.

Learn more at www.genetionary.org
For more info please talk to your doctor and/or a certified genetic counselor.

#triplenegativebreastcancer #hereditarycancer #TNBC #genes #BRCA1 #BRCA2

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#BreastCancer #PaoliCalmettes #BRCA1

2 weeks ago

Everybody has BRCA1 & BRCA2 tumor suppressor genes. BRCA genes produce proteins that help repair damaged DNA and prevent cancer. Inherited pathogenic mutations in these genes are linked to an increased risk of various types of cancer. Learn more at www.genetionary.org

Everybody has breast cancer suppressor genes.
Learn more at www.genetionary.org

#DNA #health #cancer #HereditaryCancer #genetics #geneticmutations #familyhealth #BRCA1 #BRCA2 #tumorsuppressorgenes

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DNA cowgirl

@spaceaix.bsky.social

3 weeks ago

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☣Crepie the Zombie☣

@crepe-n-sosig.bsky.social

1 month ago

Three weeks post-mastectomy. I feel better, and confidence is following suit. 🫡 #mastectomy #BRCA1 #BRCA #breastcancerawareness #geneticmutation #aestheticflatclosure #healing #surgery #results #post-op #bilateralmastectomy #preventativemastectomy #artist #musician #writer #author #confident

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Oral bacterium may promote breast cancer development and spread Researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy found that an oral bacterium commonly associated with periodontal ...

1 month ago

New Study by John Hopkins researchers finds Fusobacterium nucleatum can drive #DNA damage, tumor growth & metastasis, with heightened effects in cells with #BRCA1 gene mutations @eurekalert.bsky.social

#bcsm #hereditarycancer #womenshealth #medsky #cancerresearch #genetics

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GLOBAL Visibility aéPiot - by aePiot.ro

@globalvisibility.bsky.social

2 months ago

The aéPiot Phenomenon: Unprecedented Global Growth Analysis. A Comprehensive Business Intelligence Report on Organic Platform Expansion. The aéPiot Phenomenon: Unprecedented Global Growth Analysis A Comprehensive Business Intelligence Report on Organic Platform Expansion R...

better-experience.blogspot.com/2026/01/the-...

15 #JANUARI
multi-search-tag-explorer.aepiot.ro/advanced-sea...
#BRCA1
allgraph.ro/advanced-sea...
#DANAU #BELLANDUR
aepiot.com/advanced-sea...
headlines-world.com

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GLOBAL Visibility aéPiot - by aePiot.ro

@globalvisibility.bsky.social

2 months ago

www.ipaddress.com/website/aepi...

better-experience.blogspot.com/2026/01/the-...

#BRCA1
multi-search-tag-explorer.allgraph.ro/advanced-sea...
#DANAU #BELLANDUR
aepiot.ro/advanced-sea...
aepiot.ro

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JAMA Surgery

@jamasurgery.com

2 months ago

Forest plots show pooled estimates of breast cancer-specific mortality with odds and hazard ratios. Studies are compared with RRBM vs. control, listing events, totals, and weights. Test results and heterogeneity are given.

Risk-reducing bilateral mastectomy was associated with lower overall and breast cancer–specific mortality in female carriers of #BRCA1 and #BRCA2 pathogenic variants. ja.ma/3N4fWmd

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Genes & Development

@genesdev.bsky.social

2 months ago

⏪ G&D RECAP ⏪

🗓️ May 2025
RESEARCH PAPER: MRN–CtIP, EXO1, and DNA2–WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage
By Seppa et al., and Alessandro Vindigni
➡️ https://genesdev.cshlp.org/content/39/9-10/582.full

#DNArepair #BRCA1 #nucleases #PARP #cancer

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lanna "lvl3 phillyness" banana

@lanna.bsky.social

3 months ago

WATCH THIS

I didn't have cancer but I had diagnostic tests and surgery to lessen my risk. This was such a great watch for me while I worked through my feelings about it all. #brca1

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PLOS Biology

@plosbiology.org

3 months ago

A proposed model for cell cycle-dependent regulation of BRCA1 protein level in G1 and S phase by the countering activities of APC/CCdh1/Ube2S and Cezanne in K11-linkage specific ubiquitination of BRCA1. Dysregulation of this pathway due to loss of Cezanne or upregulation of Ube2S leads to reduced BRCA1 protein level and is associated with BRCAness in tumors.

Levels of BRCA1 fluctuate through the #CellCycle & its depletion can induce #tumors. This study identifies a new #ubiquitin modification pathway that regulates #BRCA1 stability; its dysregulation is associated with features of BRCA-mutated #BreastCancer @plosbiology.org 🧪 plos.io/4q3cxlT

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PLOS Biology

@plosbiology.org

3 months ago

A proposed model for cell cycle-dependent regulation of BRCA1 protein level in G1 and S phase by the countering activities of APC/CCdh1/Ube2S and Cezanne in K11-linkage specific ubiquitination of BRCA1. Dysregulation of this pathway due to loss of Cezanne or upregulation of Ube2S leads to reduced BRCA1 protein level and is associated with BRCAness in tumors.

Levels of BRCA1 fluctuate through the #CellCycle & its depletion can induce #tumors. This study identifies a new #ubiquitin modification pathway that regulates #BRCA1 stability; its dysregulation is associated with features of BRCA-mutated #BreastCancer @plosbiology.org 🧪 plos.io/4q3cxlT

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PLOS Biology

@plosbiology.org

3 months ago

A proposed model for cell cycle-dependent regulation of BRCA1 protein level in G1 and S phase by the countering activities of APC/CCdh1/Ube2S and Cezanne in K11-linkage specific ubiquitination of BRCA1. Dysregulation of this pathway due to loss of Cezanne or upregulation of Ube2S leads to reduced BRCA1 protein level and is associated with BRCAness in tumors.

Levels of BRCA1 fluctuate through the #CellCycle & its depletion can induce #tumors. This study identifies a new #ubiquitin modification pathway that regulates #BRCA1 stability; its dysregulation is associated with features of BRCA-mutated #BreastCancer @plosbiology.org 🧪 plos.io/4q3cxlT

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Peas & Potatoes Or Pills & Procedures?

@peasorpills.bsky.social

3 months ago

The Role of Mediterranean Diet and Intermittent Fasting in Modulating Inflammation and Clinical Biochemistry Markers in Hereditary Cancer Syndromes: A Review - Current Nutrition Reports Current Nutrition Reports - This literature review of clinical and preclinical studies aimed to analyse the latest evidence on the Mediterranean diet (MD) and intermittent fasting (IF) to prevent...

New in @springer.springernature.com: "The existing literature clearly supports the protective role of MD and IF in limiting inflammation and possibly lowering the risk of cancer in patients with HCS such as BRCA1/2 mutations." #oncology #BRCA1 #BRCA2 #cansky #oncsky
link.springer.com/article/10.1...

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Alfred Fischer

@alfredodistefano.bsky.social

3 months ago

ASSOCIATION BETWEEN TYPE AND LOCATION OF GERMLINE BRCA1/2 PATHOGENIC OR LIKELY PATHOGENIC VARIANTS WITH PHENOTYPE AND PROGNOSIS IN YOUNG PATIENTS WITH BREAST CANCER: RESULTS FROM AN INTERNATIONAL COHO... Clinical implications of specific pathogenic and likely pathogenic variant (LP/PV) types and locations in the BRCA1 or BRCA2 tumor-suppressor genes remain to be elucidated.

There are many different BRCA mutations – depending on the exon – which have different prognoses.

#breastcancer #oncology #cancer #genes #mutation #brca1 #brca2

www.annalsofoncology.org/article/S092...

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Genes & Development

@genesdev.bsky.social

3 months ago

🌟G&D SPOTLIGHT 🌟

RESEARCH PAPER: MRN–CtIP, EXO1, and DNA2–WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage
By Seppa et al., and Alessandro Vindigni
➡️ https://genesdev.cshlp.org/content/39/9-10/582.abstract

#DNArepair #BRCA1 #nucleases #PARP #cancer

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BRCA1 Variants: Contralateral vs Ovarian Cancer Risk In a groundbreaking study poised to transform our understanding of genetic cancer risks, researchers have unveiled new insights into the differential impacts of BRCA1 gene founder variants on

3 months ago

In a groundbreaking study poised to transform our understanding of #hereditarycancer risks, researchers have unveiled new insights into differential impacts of #BRCA1 gene founder variants on contralateral #breastcancer & #ovariancancer among affected women.

#bcsm #gyncsm #genetics #cancerreseach

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Breastcancer.org

@breastcancerorg.bsky.social

4 months ago

Researchers are learning that breast cancers diagnosed after childbirth can be more aggressive — especially in people with #BRCA1 or #BRCA2 mutations.

Sharing your reproductive history gives your care team critical context to better tailor your treatment plan. 🔗bit.ly/45jMZJB

#BreastCancer

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NRF2 and Estrogen Roles in BRCA1 Breast Cancer Breast cancer remains the most frequently diagnosed malignancy among women worldwide, posing a significant threat to public health despite ongoing advances in detection and treatment. Approximately 5

4 months ago

NRF2 and Estrogen Roles in #BRCA1 #BreastCancer
Via @bioengineer.org

#bcsm #hereditarycancer #womenshealth #genetics #cancerresearch #medsky

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Luc Vandingenen

@lucasdelascosas.bsky.social

4 months ago

aube.vandingenen on Instagram: "Dag tegen Kanker” (Day Against Cancer) in Belgium, and I realized there’s no better moment to speak up.🩷 1 in 8 women will face b…" Dag tegen Kanker” (Day Against Cancer) in Belgium, and I realized there’s no better moment to speak up.🩷 1 in 8 women will face breast cancer.🩷 Early detection saves lives.#breastcancerawareness #BRCA1 #dagtegenkanker #awareness #health

“I can’t out-train my DNA” 💕 #mydaughter #brca1 www.instagram.com/p/DP39O45jIH...

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5 months ago

What is cascade testing and how is it used to prevent hereditary cancer?

The infographic can be downloaded at: genetionary.org/resources/

#HereditaryCancerWeek #CascadeTesting #Previvor #CancerPrevention #Cancer #health #familyhealth #GeneticTesting #LynchSyndrome #BRCA2 #BRCA1 #CHEK2 #ATM #PALB2

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Medullary breast cancer and germline BRCA1 mutations: a possible criterion for genetic testing - Hereditary Cancer in Clinical Practice Medullary breast cancer is a rare subtype of invasive breast cancer, representing from 0.2% to 6% of all breast carcinomas, with a higher proportion among women with triple-negative breast cancer and among those with a BRCA1 mutation. This review article aims to investigate the frequency of medullary breast cancer among all breast cancers and to assess its association with BRCA1 mutations. We surveyed studies involving patients diagnosed with breast cancer that report both the histology of the breast cancer as well as the presence of BRCA1 mutations. Among women with medullary breast cancer, the proportion of cases that carry a BRCA1 mutation ranges from 3% up to 35.3%, depending on the study. Among BRCA1-mutated breast cancers, the proportion that are medullary ranges from 8 to 20%. Given the notable association between medullary breast cancer and BRCA1 mutations, we propose to consider medullary breast cancer as a criterion for genetic testing in order to improve the identification of a larger number of carriers, thereby enhancing screening and prevention strategies.

5 months ago

Medullary #breastcancer and germline #BRCA1 mutations: A potential criterion for #genetictesting.

#hereditarycancer #bcsm #cancerresearch #openaccess #medsky

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5 months ago

What are germline mutations and what role do they play in hereditary cancer?

The infographic can be downloaded at: genetionary.org/resources/

#HereditaryCancerWeek #GermlineMutations #Cancer #GeneticTesting #LynchSyndrome #BRCA2 #BRCA1 #CHEK2 #ATM #PALB2 #PTEN #MLH1 #MSH2 #MSH6 #TP53 #DNA

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A Trailblazing Geneticist Reflects On Her Life And Work Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.

5 months ago

Previvor Day Poster graphic. Previvor Day is a celebration of the courage and strength of those at higher risk for cancer due to certain inherited genetic mutations. Being a previvor does not mean you will get cancer. Previvorship is about being informed, proactive, and monitored regularly to significantly reduce the risk. Knowledge is power. Learn more about hereditary cancer at www.genetionary.org

Previvor Day is still a few day away, but this is being released now to help raise awareness and understanding of previvorship ahead of the day.

This poster can be downloaded at: genetionary.org/poster/index...

#hereditarycancer, #hereditarycancerweek, #previvor, #brca1, #brca2, #lynchsyndrome

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Sally James

@jamesian.bsky.social

5 months ago

Delightful interview with genetics pioneer Mary-Claire King of #seattle @uwmnewsroom.bsky.social
She talks about origins of her curiosity/diligence/logic that led her to discover #BRCA1 (mutation that increases risk of breast cancer) in 1990.
#breastcancer
www.sciencefriday.com/segments/dr-...

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UW Medicine Newsroom

@uwmnewsroom.bsky.social

5 months ago

A Trailblazing Geneticist Reflects On Her Life And Work Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.

Geneticist Mary-Claire King @uwmedicine.bsky.social first identified #BRCA1, the first gene linked to a hereditary form of a common cancer. She talks about her background, her research, and her approach to science on @scifri.bsky.social. @uwdeptmedicine.bsky.social

39 12 0 1

The American Journal of Human Genetics

@ajhgnews.bsky.social

6 months ago

When two plus four does not equal six: Combining computational and functional evidence to classify BRCA1 key domain missense substitutions This paper jointly calibrates multiplexed assays of variant effect (MAVEs) and computational tools, which are used in clinical variant classification. Conclusions from this work support the hypothesis...

📣New from Pew et al!
📄When two plus four does not equal six: Combining computational and functional evidence to classify #BRCA1 key domain missense substitutions

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