Latest posts tagged with #brca2 on Bluesky
In 2013, following a strong #familyhistory of #breastcancer, Jacob Johnson learned he was #BRCA2 +. Over a decade later, at the age of 53, the father of 3 was diagnosed with a rare & aggressive form of cancer in his right breast.
#bcsm #hereditarycancer #menshealth #genetics #patientexperience
BRCA2 is a key protein involved in repairing damaged DNA. Mutations in BRCA2 reduce DNA repair efficiency and increase the risk of cancers such as breast and ovarian cancer.
#CancerResearch #BRCA2
New in @nature.com!
Researchers led by Dr. Pedram Razavi of @mskcancercenter.bsky.social shows that tumors with germline #BRCA2 mutations are more likely to lose RB1 during CDK4/6 inhibitor treatment, leading to drug resistance and worse outcomes.
https://go.nature.com/4l8mZXQ
New from @nature.com: A team led by MSK breast medical oncologist Dr. Pedram Razavi found that tumors with germline #BRCA2 mutations or homologous recombination deficiency (HRD) are more likely to develop RB1 loss during treatment with CDK4/6 inhibitors, leading to therapeutic resistance.
Illustration of three pink ribbons with text: “Triple-negative breast cancer* can be a hereditary cancer red flag! * Breast cancer with no estrogen, progesterone, or HER2 receptors on the tumor. Learn more at www.genetionary.org.”
Inherited mutations in BARD1, BRCA1, BRCA2, PALB2, and RAD51D genes are linked to an increased risk for TNBC.
Learn more at www.genetionary.org
For more info please talk to your doctor and/or a certified genetic counselor.
#triplenegativebreastcancer #hereditarycancer #TNBC #genes #BRCA1 #BRCA2
Everybody has BRCA1 & BRCA2 tumor suppressor genes. BRCA genes produce proteins that help repair damaged DNA and prevent cancer. Inherited pathogenic mutations in these genes are linked to an increased risk of various types of cancer. Learn more at www.genetionary.org
Everybody has breast cancer suppressor genes.
Learn more at www.genetionary.org
#DNA #health #cancer #HereditaryCancer #genetics #geneticmutations #familyhealth #BRCA1 #BRCA2 #tumorsuppressorgenes
A new #Maturitas review examines #MaleBreastHealth 🔍 It highlights later diagnosis in men, the importance of identifying high-risk groups such as #BRCA2 carriers, and the role of imaging in assessment.
www.sciencedirect.com/science/article/abs/pii/...
📝Online now - the Forum "DNA binding is a defining feature of BRCA2 orthologs" from Alice Chanteau, Fabien Nogue, and Rajeev Kumar.
#BRCA2 #DNAbinding #homologousrecombination #DNArepair
Read it here 👉 authors.elsevier.com/a/1mTkq3S6Gf...
better-experience.blogspot.com/2026/01/the-...
#BRCA2
multi-search-tag-explorer.aepiot.com/advanced-sea...
最高裁判所図書館
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Forest plots show pooled estimates of breast cancer-specific mortality with odds and hazard ratios. Studies are compared with RRBM vs. control, listing events, totals, and weights. Test results and heterogeneity are given.
Risk-reducing bilateral mastectomy was associated with lower overall and breast cancer–specific mortality in female carriers of #BRCA1 and #BRCA2 pathogenic variants. ja.ma/3N4fWmd
FDA Approves Niraparib Plus Abiraterone for BRCA2-Mutated Metastatic Castration-Sensitive Prostate Cancer
@fda.gov
oncodaily.com/fda-approval...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Niraparib #Abiraterone #BRCA2 #ProstateCancer #MCSPC
FDA Grants Approval for AKEEGA® Innovation in Treating BRCA2-Mutated Prostate Cancer #USA #Horsham #Prostate_Cancer #BRCA2 #AKEEGA®
Using non-tumorigenic breast epithelial cells, we modeled two pathogenic BRCA2 variants:
✅ One caused reduced DNA repair & PARPi sensitivity (haploinsufficiency).
✅ The other produced a truncated BRCA2 protein that rewired gene expression & chromatin state.
#BRCA2 #CancerResearch
🚨 Exciting news! Our latest study is out in Nature Communications!
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics
New in @springer.springernature.com: "The existing literature clearly supports the protective role of MD and IF in limiting inflammation and possibly lowering the risk of cancer in patients with HCS such as BRCA1/2 mutations." #oncology #BRCA1 #BRCA2 #cansky #oncsky
link.springer.com/article/10.1...
There are many different BRCA mutations – depending on the exon – which have different prognoses.
#breastcancer #oncology #cancer #genes #mutation #brca1 #brca2
www.annalsofoncology.org/article/S092...
Variants of uncertain significance are a pain. 🧩 Mayo Clinic researchers have made major strides recently classifying 91% of previously unknown #BRCA2 variants, bringing clarity to #hereditarycancer risk. A huge win for patients & #geneticcounselors.
November marks #PancreaticCancer Awareness Month with World Pancreatic Cancer Day today. The narrative doesn’t end with hereditary BC & OVCA. As research continued, another shadow emerged. #BRCA2 mutations particularly were found to ⬆️ the risk of PC, 1 of the most silent & devastating cancers.
#ThrowbackThursday to the #HumanGenomeProject in honor of #BreastCancerAwarenessMonth - "In Dec '95, the work of >40 researchers (including @sgrayg.bsky.social) ...discovered a 2nd #BreastCancer susceptibility gene: #BRCA2... revolutionizing cancer research" 🧬
dmpi.duke.edu/news/simon-g...
Researchers are learning that breast cancers diagnosed after childbirth can be more aggressive — especially in people with #BRCA1 or #BRCA2 mutations.
Sharing your reproductive history gives your care team critical context to better tailor your treatment plan. 🔗bit.ly/45jMZJB
#BreastCancer
What is cascade testing and how is it used to prevent hereditary cancer?
The infographic can be downloaded at: genetionary.org/resources/
#HereditaryCancerWeek #CascadeTesting #Previvor #CancerPrevention #Cancer #health #familyhealth #GeneticTesting #LynchSyndrome #BRCA2 #BRCA1 #CHEK2 #ATM #PALB2
Case Report: Germline #BRCA2 Mutation and #LynchSyndrome in a Male Patient With Multiple Primary Malignancies.
#prostatecancer #menshealth #pancreaticcancer #lungcancer #hereditarycancer #genetics #openaccess #medsky #cancerresearch
What are germline mutations and what role do they play in hereditary cancer?
The infographic can be downloaded at: genetionary.org/resources/
#HereditaryCancerWeek #GermlineMutations #Cancer #GeneticTesting #LynchSyndrome #BRCA2 #BRCA1 #CHEK2 #ATM #PALB2 #PTEN #MLH1 #MSH2 #MSH6 #TP53 #DNA
Previvor Day Poster graphic. Previvor Day is a celebration of the courage and strength of those at higher risk for cancer due to certain inherited genetic mutations. Being a previvor does not mean you will get cancer. Previvorship is about being informed, proactive, and monitored regularly to significantly reduce the risk. Knowledge is power. Learn more about hereditary cancer at www.genetionary.org
Previvor Day is still a few day away, but this is being released now to help raise awareness and understanding of previvorship ahead of the day.
This poster can be downloaded at: genetionary.org/poster/index...
#hereditarycancer, #hereditarycancerweek, #previvor, #brca1, #brca2, #lynchsyndrome
As a researcher at USF who studies healthcare communication & as a patient with an inherited mutation in the #BRCA2 gene which greatly ⬆️ my lifetime risks for #breastcancer, #ovariancancer and #pancreaticcancer — I’ve seen how uncertainty plays out in personal & life-altering decisions.
❔ Did you know? Germline variants in the #PALB2 gene significantly increase breast cancer risk - often nearly as much as variants in #BRCA1 and #BRCA2.
Explore the most comprehensive, curated PALB2 data available - completely free in Mastermind! mastermind.genomenon.com/users/sign_u...
#BRCA2
I tested positive for BRCA 2 gene in April this year. I had a colonoscopy just recently as bowel habits changed & bowel tumours in past. Now waiting results of 5 polyps removed 2 of them 1cm in size.
It’s important that we talk about the importance of testing and family history
My insurance company hates to see me coming... 😐
#BRCA2
#PsoriaticArthtitis
To read more about these breast cancer research studies and others, visit bit.ly/3GdG4HZ.
#breastcancer #breastcancerresearch #chemo #chemotherapy #radiation #breastcancertreatment #breastcancerwarrior #breastcancersurvivor #brca1 #brca2 #brca
