#BetaCell

3 months ago

Higher placental expression of GKN1 is associated with diminished #betacell function in #pregnancy and #GDM #DiabetesResearch

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3 months ago

Production of #insulin can be sustained during DNA-damage mediated #betacell senescence

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European Association for the Study of Diabetes

3 months ago

The Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves #betacell function in stem cell-derived #islets under metabolic stress. #T1D #SC-islets #CellTherapy

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@easdnews.bsky.social

3 months ago

⏰Last call - applications closing soon!
Apply now for EASD’s 1st Immunology School for Endocrinology to explore
✅ Latest #immunology concepts in #T1D,
✅ Early detection and disease staging,
✅ Disease-modifying therapies and #betacell replacement
👉 www.easd.org/education/me...

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Daniel Drucker

@danieljdrucker.bsky.social

4 months ago

Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery | Keystone Symposia Join us at the Keystone Symposia on Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery, March 2026, in Breckenridge, with field leaders!

Deadlines are approaching (some next week!) for @keystoneSymposia.bsky.social #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! See scholarship, abstract and discount reg dates: keysym.us/KSDiabetes26 #KSDiabetes26

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SPINA Team

@spinateam.bsky.social

5 months ago

Information processing structure of the feedback model. [G](t): glucose concentration; S(t): insulin secretion rate; [I](t): insulin concentration; M(t): proximal insulin signalling; N(t) distal insulin signalling; P(t): constitutive glucose production rate; Q(t): regulated glucose production rate; W(t): intestinal glucose absorption rate; R(t): glucose arrival rate. G1 and G3 represent gains of ASIA elements. Units of measurement are displayed in the small, rounded boxes with red margins.

Circular Maps of the correlation networks of novel biomarkers for insulin-glucose homeostasis with anthropometric and experimental data in the NHANES cohort (A) and the clamp study (B). Shown are significant correlations (p < 0.05) only, and line thickness indicates the strength of negative (blue) or positive (red) correlation. A green segment in the inner ring indicates a reduction of the corresponding biomarker in subjects with diabetes.

Plot of SPINA-GBeta against SPINA-GR, suggesting a compensatory rise of beta cell function in the case of declining insulin sensitivity in subjects with normal glucose homeostasis (green dots). This ability of beta cell compensation is partly lost in subjects with prediabetes (orange dots) or diabetes (red dots).

Mathematical modelling of #insulin-#glucose #homeostasis delivers new and improved methods for metabolic endotyping. #prediabetes #diabetes #metabolic_syndrome #betacell pubmed.ncbi.nlm.nih.gov/36271244/ doi.org/10.1038/s415...

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UPENN_ITMAT

@itmat.bsky.social

6 months ago

Molecular insights to potentially prevent #BetaCell failure in #Type2Diabetes doi.org/10.1016/j.mo... #T2D #DiabetesResearch #IsletBiology #TranslationalScience

1 1 0 0

@dream-diabetes.bsky.social

6 months ago

Insights into the role of the #betacell in type 2 diabetes #Review #T2D #Islets #DiabetesResearch #Endocrinology #MedSky

1 1 0 0

DREAM Theme

7 months ago

Happening TODAY! Join the DREAM Trainees in 500 JBRC from 12 - 1 p.m., where Corey Sanderson (Doucette lab) and Caitlin Menzies (@verndolinsky.bsky.social lab) will share insights into their research methods. Don’t miss it! 🔬🧬 @chrimanitoba.bsky.social #diabetes #research #mice #betacell #t2d

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Verapamil and low-dose anti-mouse thymocyte globulin combination therapy stably reverses recent-onset type 1 diabetes in NOD mice by acting on the beta cell and immune axes - Diabetologia Aims/hypothesis Verapamil, a calcium channel blocker, and low doses of anti-thymocyte globulin (ATG) have individually shown efficacy in preserving beta cell function in people with recent-onset sympt...

7 months ago

Verapamil + low-dose ATG = a powerful combo 💪🏼! This dual therapy reversed T1D in NOD mice by preserving beta cells and modulating autoimmunity - a step closer to curative strategies 👩🏽‍🔬. #T1D #Type1Diabetes #BetaCell #Immunotherapy link.springer.com/article/10.1... 🔓

4 1 0 0

Lorenzo Piemonti

@piemontil.bsky.social

8 months ago

Future Directions and Clinical Trial Considerations for Novel Islet β-Cell Replacement Therapies for Type 1 Diabetes Type 1 diabetes results from the immune-mediated loss of insulin-producing pancreatic islet β-cells, rendering those affected dependent on exogenous insuli

Can β-cell replacement therapies for type 1 diabetes move beyond being a last resort?
In this new Diabetes article, we explore what’s possible, what’s needed, and what questions remain.
📄 doi.org/10.2337/dbi2...
#T1D #BetaCell #DiabetesResearch

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Endocrine Society Journals

@endosocjournals.bsky.social

8 months ago

Effect of Time-Restricted Eating on β-Cell Function in Adults With Type 2 Diabetes AbstractContext. Time-restricted eating (TRE), which consists of restricting the eating window to typically 4 to 8 hours (while fasting for the remaining h

Effect of time-restricted eating on β-cell function in adults with type 2 #diabetes. Featured study in #JCEM #FreeToView #BetaCell #T2D academic.oup.com/jcem/article...
@endocrinesociety.bsky.social

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@timbeardsley.bsky.social

8 months ago

The role of METRNL in maintaining #betacell function and identity by preventing beta-to-alpha cell trans-differentiation under metabolic stress #DiabetesResearch #Islets

0 0 0 0

8 months ago

Effect of Time-Restricted Eating on β-Cell Function in Adults With Type 2 Diabetes AbstractContext. Time-restricted eating (TRE), which consists of restricting the eating window to typically 4 to 8 hours (while fasting for the remaining h

Effect of time-restricted eating on β-cell function in adults with type 2 #diabetes. Featured study in #JCEM
#FreeToView #BetaCell #T2D
doi.org/10.1210/clin...
@endosocjournals.bsky.social
@endocrinesociety.bsky.social

1 0 0 0

8 months ago

A diet rich in polyphenols, fibre and polyunsaturated fats significantly lowers #ApoC-III in people with #T2D, and this could be linked to reduced liver and pancreatic fat and improved #betacell function #DiabetesResearch #Endocrinology #Nutrition #MedSky

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9 months ago

New data on signalling pathways involved in #betacell stress and failure, providing clues on how to prevent loss of beta cell mass in #diabetes #Islets #DiabetesResearch #Endocrinology #MedSky

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BMP5 signalling in beta cells and the impact on insulin secretion in the context of type 2 diabetes - Diabetologia Aims/hypothesis Identifying signalling pathways that are important in pancreatic beta cell stress and failure can give insight into possible treatment options to prevent the loss of functional beta ce...

9 months ago

Identifying signalling pathways important in beta cell stress and failure gives insight to prevent the loss of beta cell mass in diabetes. A new study shows the link between BMP5 expression in beta cells and #betacell function link.springer.com/article/10.1... 🔓 #diabetes

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DREAM Theme

@dream-diabetes.bsky.social

9 months ago

🎉 Huge congrats to Jasmine Pipella and @thompsonisletlab.bsky.social on their new publication! 📄 Amazing to see your hard work driving important progress in the field. 🙌 Always making the DREAM theme proud! #type1diabetes #betacell @chrimanitoba.bsky.social diabetesjournals.org/diabetes/art...

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Transplant International

@transpl-int.bsky.social

9 months ago

THE APRIL ISSUE IS ONLINE!!

What is the destiny of beta cell replacement therapy?

Check it out here: shorturl.at/HmFvx

#april #issue #future #betacell #replacement @esottransplant.bsky.social

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Santiago Rodríguez Seguí

@rseguilab.bsky.social

9 months ago

Balanced work & relaxation today—excited to present the work of our lab @ifibyne tomorrow at Peking University Third Hospital’s Endocrinology Department! #BetaCell #DiabetesResearch #StemCells

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Endocrine Society Journals

10 months ago

Study in a #Zebrafish model on the impact of exocrine malfunction on #BetaCell function #T1D #DiabetesResearch #Endocrinology #MedSky

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@endosocjournals.bsky.social

1 year ago

Effects of Hypertriglyceridemia With or Without NEFA Elevation on β-cell Function and Insulin Clearance and Sensitivity AbstractContext. Hypertriglyceridemia is a risk factor for developing type 2 diabetes (T2D) and might contribute to its pathogenesis either directly or thr

Effects of #hypertriglyceridemia with or without NEFA elevation on β-cell function and #insulin clearance and sensitivity: new Featured study in #JCEM. #FreeToView
#T2D #FattyAcids #lipids #BetaCell #diabetes
@endocrinesociety.bsky.social
doi.org/10.1210/clin...

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Stephen Stone, MD 🔬🧬🐁✏️

@stevestonedraws.bsky.social

1 year ago

Absolutely thrilling seminar by Dr. Jing Hughes on the role of primary #cilia in the metabolism of the pancreatic #BetaCell

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Single-cell RNA sequencing identifies endothelial-derived HBEGF as promoting pancreatic beta cell proliferation in mice via the EGFR–Kmt5a–H4K20me pathway - Diabetologia Aims/hypothesis Pancreatic beta cell mass is dynamically regulated in response to increased physiological and pathological demands. Understanding the mechanisms that control physiological beta cell pr...

1 year ago

Endothelial-derived HBEGF regulates #BetaCell #proliferation via the EGFR–Kmt5a–H4K20me signalling pathway, providing a potential target for #diabetes treatment tinyurl.com/mtynftc8

2 0 0 0

1 year ago

Fascinating new study on mechanisms for #WolframSyndrome
#BetaCell #Endocrinology

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