Latest posts tagged with #interferon on Bluesky
Exogenous #EBNA1 promotes #ImmunotherapyResistance by enhancing #ADAR1 translation via the IGF2BP3/EIF4G1 complex, suppressing #Interferon signaling and #ImmuneResponse in #EBV-associated cancers.
#STTT #OpenAccess: doi.org/10.1038/s413...
@cp-cell.bsky.social is on 🔥 with #immunemetabolism! Zheng &co show that excessive glycolysis-driven pyrivate cause pyruvylation of STAT1 preventing #interferon signaling 👉 doi.org/10.1016/j.ce... & Finley &co show that ACO2 clears citrate preventing integrated stress response & kidney degeneration👇
Leslie Chan @stanfordimmunology.bsky.social, Catherine Blish @blishlab.bsky.social and colleagues @stanfordmedicine.bsky.social identify #Interferon activation and #NKG2D expression as key determinants of #NKcell antibody-dependent cellular cytotoxicity (#ADCC) in #SARS-CoV-2 infection
Epigenetic dysregulation of IRF9 drives excessive #interferon signaling in #COPD
By M. Llamazares-Prada, R. Jurkowska & colleagues @biomedx.bsky.social & Cardiff University
🗞️ doi.org/10.1038/s44321-026-00386-9
In the final stretch of my DPhil at @ox.ac.uk, working on how the soluble interferon receptor IFNAR2a modulates type I interferon signalling in infection and autoimmunity.
Excited to see where this work leads next!
#Immunology #InnateImmunity #Interferon
🔗 Rehwinkel Group lab page:
www.rdm.ox.ac.uk/about/our-di...
#WIMMSpotlight #WIMMCommunity #Immunology #InnateImmunity #AntiviralResearch #Interferon #PhDStudent #MRCWIMM
#interferon signature: doi.org/10.1016/j.ki...
#prognosis signature: doi.org/10.1681/asn....
Our new preprint on #SARSCoV2 nsp14 #exonuclease function in replication fidelity and fitness. ExoN- viruses are attenuated in vitro and in vivo but w/o #interferon signaling replication is largely restored! Suggests nsp14 plays a role in innate antagonism in vivo www.biorxiv.org/content/10.6...
Dr. @BrandiReeves1 #MPNChallenge ™ study is uncovering how MPNs damage the kidneys and if interferon-alpha might protect them. Donate today to help make more research like Dr. Reeves' a reality: https://goto.mpnresearchfoundation.org/48Xj643
#MPNResearch #RareDisease #Interferon
Oncogenic MUC1-C/M1C protein confers #Osimertinib resistance in #NSCLC cells by driving an inflammatory memory response via the STAT1 and #Interferon type I/II pathways and is a target for M1C ADC treatment. @harvardmed.bsky.social
#OpenAccess: doi.org/10.1038/s413...
☕Williams et al. report a growth arrest mechanism in residual #cancer persister cells through targeted #therapy - induced upregulation of type I #interferon signalling, which is negatively regulated by apoptotic DNA endonuclease DFFB to allow tumour relapse.
bit.ly/4aibIAN
Dot plot of pathway analysis for MDM vs AM responses
This team effort revealed several interesting findings...
First, we found that while all #macrophages generated strong #interferon responses to Mtb in vitro, AM from both species showed weaker inflammatory responses to Mtb than human MDM or murine BMDM, despite higher baseline levels.
(2/5)
Recent review shows that type I interferon is overactive in kids with lupus, driving inflammation, highlighting key genes, biomarkers, and new treatment options like IFN blockers & JAK inhibitors.
#Meded #SoMe4PedSurg #Pediatrics #PediatricSLE #Interferon
link.springer.com/article/10.1...
⏰#October issue of #Genes & #Immunity is online!
👉Read abt #autism, #viral #infection, #inflammatory #bowel #disease #IBD, #Alzheimer #disease, #interferon #responses, #colorectal #cancer, #periodontitis, #microRNA, #lupus, #thymocyte & #celiac #disease
www.nature.com/gene/volumes...
Your immune system remembers skin inflammation long after it resolves because of #interferon alpha!
Check out our new paper describing these findings just published at
@jimmunol.bsky.social 👇👇👇
It was amazing working on this with my role model @drshrutinaik.bsky.social
This study links the cyclic guanosine monophosphate-adenosine monophosphate synthase & stimulator of #Interferon genes pathway to #Retinal #Inflammation, offering new treatment strategies for #Uveitis. @fudan-university.bsky.social #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
#IRF3 in #viral #infections: more than just triggering the #interferon #response
#Genes & #immunity @springernature.com
www.nature.com/articles/s41...
Kudos to DeRisi and colleagues on this exciting finding.
#interferon #immunity #infection @czbiohub
Get out of London! A track to be played loud ... youtu.be/6u3UNwybclo?...
#Interferon #GetOutOfLondon
Big congrats to Vinnie Graziano @vinnieviruses.bsky.social who led the project and huge thanks to our great collaborators: Jennifer Porat, Thomas Carell, Franck Barrat, Beiyan Zhou, Sivapriya Kailasan Vanaja, Michael Wilson, and Penghua Wang!! #innate_immunity #interferon #celldeath
Differential modulation of #Interferon and Cell Death Responses defines #Human vs Avian #Influenza A Virus Strain-Specific Virulence and guides Combination #Therapy, etidiohnew.blogspot.com/2025/08/diff...
📈 Last week I had the chance to present my project on the influence of #interferon on antigen processing by the proteasome at the 2nd #Heidelberg Interferon Symposium! 🦠🧬🧫 1/3
#ToStressOrNotToStress! @christinviral.bsky.social @cadwelllab.bsky.social show @naturemicrobiol.nature.com that stress drives #interferon stimulated genes to protect against an enteric virus! After immune suppression by stress-induced glucorticoids, CD8 T cells get activated protecting the host!
🚨🚨 News from the @castello-lab.bsky.social and @shabazlab.bsky.social. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon. #RNA, #immunity, #interferon, #host-virus www.biorxiv.org/content/10.1...
Tomorrow, in #PreprintClubHub1 Mount Sinai’s Rachel Geltman @rachelgeltman.bsky.social will present a #preprint from @asmita_panthi about the way alternate isoforms of IRF7 differentially regulate #interferon expression to tune response to viral infection. 7️⃣ 🎶 🤒
www.biorxiv.org/content/10.1...
#IntegratedStressResponse #UnfoldedProteinResponse #DendriticCells #Interferon #ISR #UPR #DCs #IFN @ciml.bsky.social @cnrs.fr @cnrsbiologie.bsky.social @univ-amu.fr
ONLINE COVER: Lymph Nodes Get a Remodel. Fibroblastic reticular cells (FRCs) are stromal cells that coordinate structural remodeling and adaptive immune responses in the lymph node. Using single-cell transcriptomics and high-resolution microscopy, Lütge et al. comprehensively characterized the stromal cell landscape of human lymph nodes during quiescence and inflammation. Inflammation drove lymph node remodeling including the expansion of peptidase inhibitor 16 (PI16)+ FRCs in macrophage-rich perivascular niches. This month’s cover image shows an inflamed human lymph node that has undergone expansion of podoplanin+ FRCs (purple) near alpha smooth muscle actin (ACTA2)+ vascular smooth muscle cells (green) to support immune cell infiltration and BCL6+ germinal center B cell (orange) activity. Credit: Lisa Kurz/Kantonsspital St. Gallen
The May issue of #Science #Immunology is out now!
This week: #interferon regulates #thymic epithelial cell differentiation; #efferocytosis determines #alveolar #macrophage functional plasticity: & mapping the #stromal cell landscape of human #LymphNodes!
science.org/toc/sciimmunol/10/107
#ImmunometabolismPower! Artyomov, Paulenda &co show @natmetabolism.nature.com that #itaconate potentiates #interferon production & bloks late NLRP3 activation in response to microbial encounter by inhibiting a mitochondrial peroxidase thus increasing mitochondrial ROS!
www.nature.com/articles/s42...
NEW RESEARCH—Serum type I #interferon score as a disease activity biomarker in patients with diffuse cutaneous #SystemicSclerosis: a retrospective cohort study bit.ly/3Eh7Q5r #Medsky #Rheumsky
🚨 New study in @pnas.org ! 🚨
We identified MITD1, a brain-specific interferon-inducible factor that 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝘀 𝗳𝗹𝗮𝘃𝗶𝘃𝗶𝗿𝘂𝘀 𝗿𝗲𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻, including WNV, USUV, ZIKV & DENV.
🔗 Read the paper: www.pnas.org/doi/10.1073/...
👇 Thread with take-home messages below!
#Virology #Flavivirus #Interferon
