Latest posts tagged with #protacs on Bluesky
👀 In our new application note, we demonstrate how fluorescence cross-correlation spectroscopy (FCCS) can be performed on the EI-FLEX system to characterise the formation of a ternary complex > excitinginstruments.com/resource-lib...
#ternarycomplex #fccs #PROTACs #molecularglues
At the final day of the @novalix.bsky.social conference? If you haven't had chance to meet with Audrey and Jake yet, there's still time to discuss how confocal fluorescence spectroscopy can accelerate your induced-proximity drug screening ⚡
#ternarycomplex #molecularglues #PROTACs #novalix
🥳 Our 2nd most downloaded article in 2025:
Targeted protein degradation for cancer therapy
#PROTACs #Degraders @NatResCancer
#NRCtop10of2025
A successful PROTAC Hackathon hosted at the@crick.ac.uk:
• 34 participants
• 24 reviews generated
• 100% reported improved understanding
Organised by the Chemical Probes Portal with academic & industry collaboration.
Next Hackathon: EUFEPS–SITELF 2026 in Naples 🇮🇹
#ChemicalProbes #PROTACs #EUFEPS
🇺🇸 Heading to #Novalix? Learn how confocal fluorescence spectroscopy accelerates induced-proximity drug screening. Meet our US team, Audrey & Jake, to discuss #biophysicalscreening, #molecularglues and #PROTACs, #single-molecule #proteindynamics, and more. Look out for their booth and poster!
#NewTeamMembers! Happy to welcome Julia Hierholzer, Dilara Güler, Marcus Kraus and Shipeng Song to our research team!!🎉🎉 We’re thrilled to have them on board. Welcome, Julia, Dilara, Marcus, and Shipeng!! 👩🔬🧑🔬
#chemistry #photochemistry #electrochemistry #dominoreactions #onepotreactions #PROTACs
This review outlines #ubiquitination as a key regulator of #cellularhomeostasis, its dysregulation in major diseases, and emerging therapeutic strategies including #PROTACs, molecular glues, and clinical advances targeting this pathway.
#OpenAccess in #STTT: doi.org/10.1038/s413...
🔥Tumour-enriched amino acid mimic drives in situ assembly of #PROTACs and immune-engaging #nanoparticles, boosting #Tcell activation 14.8× and causing strong tumour regression with minimal toxicity.
ow.ly/WKzy50XQhjE
#Tumour #CancerResearch #Immunotherapy #Nanomedicine
Reviewing #BCL2 family proteins, their regulation & functions, their role in #Apoptosis, with a discussion on the development & potential of BH3-mimetics, #PROTACs, ADCs and tools targeting the BH4 domain of BCL2. @goetheuni.bsky.social
#OpenAccess: doi.org/10.1038/s413...
Also thanks to @ki.se, @scilifelab.se, @novonordisk.bsky.social, Cancerfonden, and Barncancerfonden for continued support.
#NUDT5 #metabolism #thiopurines #chemotherapy #cancer #biomarker #PROTACs #TPD
4/4
🧪 Die meisten #Medikamente blockieren Proteine bzw. ihre Herstellung. #PROTACs machen es anders: Sie lassen durch zelleigene „Müllschredder“ störende Proteine beseitigen.
🔗 Der Pharmazeut M. Schubert-Zsilavecz erläutert die neuen Wirkstoffe im #UniReport: aktuelles.uni-frankfurt.de/unireport/pr...
The Booming Targeted Protein Degradation Market Expected to Reach $9.85 Billion by 2035 #USA #Delray_Beach #Arvinas #PROTACs #Targeted_Protein_Degradation
Proximity-induced drug modalities — such as #PROTACs and molecular glue degraders — aim to eliminate or modulate disease-related proteins, many of which have long been considered undruggable.
👉 New tools, including AI and machine learning, are expected to help accelerate progress.
Discovery of BMS-986365, a first-in-class dual androgen receptor ligand-directed degrader (AR LDD) and antagonist, for the treatment of advanced prostate cancer #proteindegradation #protacs aacrjournals.org/clincancerre...
Binary complexes in green and red #Protacs (Turn by 180°)
Happy to share that our project on novel #antiviral #PROTACs has been awarded funding by the #VolkswagenFoundation!🎉 A big thank you to the @volkswagenstiftung.de for supporting our research, and to the #MarschallGroup (Institute of Virology, @fau.de) for the great collaboration!👍
Big congratulations to Professor Alessio Ciulli, the first Gates Cambridge Scholar to be elected a Fellow of the Royal Society - www.gatescambridge.org/about/news/g...
@uniofcam.bsky.social @gatesfoundation.bsky.social
#chemistry #protacs #impact
Cool #TPD concept
Indolequinone-based #hypoxia activated #PROTACs (HAP-TACs) selectively degrade BRD4 in hypoxic cancer cells | ChemRxiv - doi.org/10.26434/che...
🧲 Chemical Inducers of Proximity at #ChemBioParis2025
Explore how small molecules drive protein interactions to rewire biology.
🎙 Featuring Ivan Đikić & Fleur Ferguson
📍 Paris | 🗓 Oct 6-9, 2025
🔗 chembioparis2025.com
#ChemicalBiology #PROTACs #MolecularGlues #DrugDiscovery
#ICBS2025 #ECBS2025
Here’s to decoding the ‘ub-code’, one complex at a time 🔬✨
#CryoEM #CRLs #UbiquitinCode #TPD #PROTACs #glues #MolecularMachines
SciTech Chronicles. . . . . . . . .April 19th, 2025
bit.ly/stc041925
#MAP #biomass #grasslands #NutNet #siderite #Sharp #Gale #water #Beekee #microserver #"pop-up digital classroom" #"Raspberry Pi-based" #biomechanical #real-time #dynamic #static #CD36 #uptake #PROTACS #"enhanced uptake"
Oerth Bio's Innovative PROTAC Technology: Revolutionizing Agriculture with Targeted Protein Degradation #USA #Durham #Agriculture #Oerth_Bio #PROTACs
This afternoon has been all about the latest techniques - protein degrading #PROTACs, AI support in #drugdiscovery, and small molecules modifying #epigenetics. These techniques have been applied to #cancer #malaria and #antibiotic resistance and demonstrate promising possibilities for the future. 🧪
🧪 Aganitha Igniva™ AI Agents for Molecule & Material Engg.: Balancing novelty with developability
✅ #GenAI for #SMOLs, covalent binders, #PROTACs
✅ De novo #Materials: #Surfactants, fragrance molecules, photoactivators, biopolymers
✅ ADMET, skin sensitization, emulsification
Yesterday's conference was all things #drugdiscovery at AstraZeneca in Cambridge.
From small molecules to PROTACs, researchers are tirelessly streamlining modelling and computational methods to improve the efficiency of candidate discovery.
#MedicinalChemistry #PROTACs #Research #Science
Happy to welcome Julia Ryll & Aya Alfarem to our research team!!🎉🎉 Julia joined us as a PhD student and is developing #anticancer #prodrugs and #PROTACs, while Aya, our new Master's student, is working on #electrochemical #CHfunctionalization! We’re thrilled to have them on board! #Welcome #ChemSky
Next steps for targeted protein degradation: Cell Chemical Biology www.cell.com/cell-chemica... #TPD #PROTACs
Aram Davtyan giving an awesome poster presentation about our work modeling protein-small molecule-protein ternary complexes at @keystonesymposia.bsky.social Proximity-Based Therapeutics! #biotech #drugDev #degraders #molecularGlues #PROTACs
Find the poster here: www.deeporigin.com/academic-pos...
Talking about VHL-based #PROTACs: Check out our newest publication from the @proxidrugs.bsky.social consortium in which we propose & exemplify a generalizable workflow for the validation of E3 ligands for developing PROTACs.
pubs.acs.org/doi/10.1021/...
