Latest posts tagged with #Bcell on Bluesky
- Atypical Memory #BCell Enrichment: Expanded B-cell clones in PEA+ patients are disproportionately found within the atypical memory subset rather than classical memory pools.
-Genetic Motifs: These clones exhibit a significant overrepresentation of RKH/Y5 heavy-chain motifs,
Thrombotic complications in #longCOVID resemble those in acute
infection,suggesting a shared mechanism.
The development of prothrombotic platelet activating antibodies is strongly associated with the selective expansion of atypical memory #Bcell (atMBC)clones & a coordinated inflammatory environment
" #Obinutuzumab ( #Gazyva ) appears set to add systemic #lupus erythematosus ( #SLE ) to its list of approved indications, as results from a phase III trial showed it was significantly more effective than placebo, with no new safety concerns.": buff.ly/WWFikk5
via @medpagetoday.com
#BCell #MedSky
New data from Heidi Rysan, @rdekoter.bsky.social and colleagues @schulichmeddent.bsky.social - "H195Y mutation of #IKZF3 identified in a mouse model of precursor #Bcell acute lymphoblastic #Leukemia impairs transcriptional repression activity and increases protein stability"
OUTLOOK: Flicking the switch for B cell development
By Ashley Ng and Stephen Nutt
➡️ https://genesdev.cshlp.org/content/40/3-4/143.full
Also read:
➡️ https://genesdev.cshlp.org/content/40/3-4/233.full
WEHI (The Walter and Eliza Hall Institute of Medical Research) University of Melbourne
#Bcell
RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch
By Tingvall-Gustafsson et al., and Mikael Sigvardsson
➡️ https://genesdev.cshlp.org/content/40/3-4/233.full
Linköping University @lunduniversity.bsky.social
#hematopoiesis #Bcell #transcriptionfactor #epigenetics
#Medsky🧪#IDsky #immunosky #publichealth #Affinitymaturation in germinal centres (GCs) diversifies the #Bcell response & results in antibodies with improved antigen binding. However, antibodies generated early in a response can reshape ongoing GC selection,
Dr. Facundo Batista at the @ragoninstitute.bsky.social has been named the 2026 recipient of the AAI-BioLegend Herzenberg Award by @aai.org.
The award recognizes investigators who have made outstanding contributions to the field of #BCell biology: https://bit.ly/3Mrw2pQ
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch
By Tingvall-Gustafsson et al., and Mikael Sigvardsson
➡️ genesdev.cshlp.org/content/early/2025/11/20...
#hematopoiesis #Bcell #transcriptionfactor #epigenetics
#Medsky🧪 #IDsky #immunosky #Casereport identified a case of very #longCOVID caused by impaired #Bcell –mediated #immunity to #SARSCoV2 in a patient with #Goodsyndrome. Immunoglobulin replacement therapy alone was sufficient to achieve clinical & radiological resolution.
Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia
This study highlights HZX-02-059, a dual-target inhibitor of #PIKfyve & #Tubulin, as lethal to #Bcell #AcuteLymphoblasticLeukaemia cells, underscoring its potential as a #therapeutic candidate for targeted #CancerTherapy. #medsky
Read: link.springer.com/article/10.1...
📖
“•Naive myelin-reactive B cells enter the brain and capture antigen
•B cells capturing antigen in the brain die by activation-induced cell death
•EBV protein LMP1 can rescue B cells from activation-induced cell death
•B cells rescued after antigen capture induce MS-like lesions”
#Bcell #Antigen
#Medsky🧪 #immunosky #publichealth @sciimmunology.bsky.social This study’s demonstrates that the memory #Bcell (MBC) responses responsible for lifelong allergies are not irreversibly committed to producing pathogenic IgE.
www.science.org/doi/10.1126/...
www.science.org/doi/epdf/10....
Immcantation.org user or interested in #Bcell & #Tcell repertoire analysis? #AIRRseq
🚨Register now for the "2026 Immcantation Users Group Meeting"
🗓️FREE virtual meeting on January 22, 2026 from 10AM – 1:30PM ET.
🔗Program & registration: immcantation.github.io/users-meetin...
New research reveals a link between Epstein-Barr virus (EBV) & Primary Sclerosing Cholangitis. Systematic #immuneprofiling shows that #PSC associated T & B cells target #EBV, suggesting it may drive pathogenesis.
www.nature.com/articles/s41...
#Omics #LiverDisease #Autoimmunity #Bcell #Tcell
-Early Antigen Capture: Neutrophils rapidly migrate to injection sites, engulfing antigens & transporting them to lymph nodes, initiating immune activation.
- #BCell Help: They produce 🔑 #Bcell survival factors (BAFF,APRIL) that promote B cell activation, differentiation & robust antibody production
Researchers in #ScienceTranslationalMedicine find a distinct #Bcell and antibody profile in infants and mothers in an Older Order Mennonite farming community, associated with lower incidence of egg #allergy. https://scim.ag/48rPBGS
& plasmacytes that produce 🦠 -specific high-affinity antibodies. Circulating Tfh cells from #COVID patients support in vitro #Bcell differentiation into antibody-secreting plasma cells & antibody production.
journals.plos.org/plosmedicine...
💉 may promote a more regulated #Bcell response, favoring germinal center reactions with higher somatic hypermutation, which contrasts with the dysregulated extrafollicular #Bcell responses seen in severe COVID cases.
You know what's great about getting a flu shot?
There is an army of twinks like this one in your body that are being stuffed with filthy genetic material until they start squirting antibodies all over the place the the dirty sluts they are.
B stands for Bitch!
#CellsAtWork #HatarakuSaibou #BCell
www.science.org/doi/10.1126/...
📖”This marks a critical point in B cell fate commitment, whereby CD21 down-regulation initiates EF B cell proliferation and differentiation, driving the rapid production of ASCs. “
#Bcell #SLE #lupus
www.nature.com/articles/s41...
📖 “Distinct autoreactive CD19– plasma cell subsets accumulate in lupus-prone mice”
#SLE #lupus #Bcell
www.science.org/doi/10.1126/...
“These EBV-infected B cells with antigen-presenting abilities had the capacity to activate autoreactive helper T cells, setting off a chain reaction where those T cells could activate other autoreactive B cells, including uninfected ones.”
#SLE #Bcell #EBV
AMP just published!
"Conjunctival Extranodal Marginal Zone Lymphoma Presenting as Entropion"
Full paper here:
www.actamedicaportuguesa.com/revista/inde...
#conjunctivalneoplasms #entropion #lymphoma #bcell #actamedicaportuguesa
#Article in @MedComm_MC
Discovering Heterogeneous Leukocytes Subsets Associated With Alcoholic Steatohepatitis by #scRNAseq Analysis doi.org/10.1002/mco2...
#AlcoholicLiverDisease #AlcoholicSteatohepatitis #Bcell #ImmuneCell #Neutrophil #tSNEs
As #ACRConvergence unfolds, one session really stood out “Driving CAR-T into the Future.”
With discussion of next-gen #Bcell targets (CD19, CD20, BCMA, autoreactive subsets), the field is moving from broad depletion to tailored immune precision.
#Lupus #AutoimmuneDisease #CARTcells
that actively promote the development of broadly neutralizing #Bcells. This could lead to more durable #immunity against a wider range of current & future variants.
- The superior ability of booster 💉 to broaden #Bcell #immunity can inform #publichealth strategies
scim.ag/46IjMJ0
The process of #Bcell broadening
- After the booster 💉the immune sys recalls & reactivates mBcells created during previous vaccinations or infections. This process boosts the production of antibodies that are specific to the original viral strain.
#Medsky🧪 #IDsky #immunosky #virosky #Publichealth Based on a study in @sciimmunology.bsky.social , a #covid booster immunization drives a germinal center mediated broadening of #Bcell responses by recalling existing #memoryBcells
www.science.org/doi/10.1126/...
📖”Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation”
#RA #Tcell #Bcell #arthritis
